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. 2023 Jan 1;74(1):7-11.
doi: 10.1093/jxb/erac444.

Do plants drive translation reinitiation to dodge nonsense-mediated decay?

Yihan Dong  1 , Lyubov A Ryabova  1
Affiliations
Free PMC article

Do plants drive translation reinitiation to dodge nonsense-mediated decay?

Yihan Dong et al. J Exp Bot. .
Free PMC article

Abstract

This article comments on:

Cymerman MA, Saul H, Farhi R, Vexler K, Gottlieb D, Berezin I, Shaul O. 2023. Plant transcripts with long or structured upstream open reading frames in the NDL2 5ʹ UTR can escape nonsense-mediated mRNA decay in a reinitiation-independent manner. Journal of Experimental Botany 74, 91–103.

Keywords: NMD; UPFs; mRNA degradation; post-transcriptional control; proteomics; translation reinitiation.

References

    1. Buhler M, Steiner S, Mohn F, Paillusson A, Muhlemann O.. 2006. EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3’ UTR length. Nature Structural & Molecular Biology 13, 462–464. - PubMed
    1. Cymerman MA, Saul H, Farhi R, Vexler K, Gottlieb D, Berezin I, Shaul O.. 2023. Plant transcripts with long or structured upstream open reading frames in the NDL2 5ʹ UTR can escape nonsense-mediated mRNA decay in a reinitiation-independent manner. Journal of Experimental Botany 74, 91–103. - PubMed
    1. Drechsel G, Kahles A, Kesarwani AK, Stauffer E, Behr J, Drewe P, Ratsch G, Wachter A.. 2013. Nonsense-mediated decay of alternative precursor mRNA splicing variants is a major determinant of the Arabidopsis steady state transcriptome. The Plant Cell 25, 3726–3742. - PMC - PubMed
    1. Fatscher T, Boehm V, Weiche B, Gehring NH.. 2014. The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay. RNA 20, 1579–1592. - PMC - PubMed
    1. Gohring J, Jacak J, Barta A.. 2014. Imaging of endogenous messenger RNA splice variants in living cells reveals nuclear retention of transcripts inaccessible to nonsense-mediated decay in Arabidopsis. The Plant Cell 26, 754–764. - PMC - PubMed

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