Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)

doi:10.1515/cclm-2022-1270

. 2023 Jan 16.

doi: 10.1515/cclm-2022-1270. Online ahead of print.

Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)

Paul Collinson^{1

2}, Kristin M Aakre^{3

4}, Amy Saenger^{5

6}, Rick Body^{7

8

9}, Ole Hammarsten¹⁰, Allan S Jaffe¹¹, Pete Kavsak¹², Torbjørn Omland^{13

14}, Jordi Ordonez-Lianos^{15

16}, Brad Karon¹⁷, Fred S Apple^{5

6}

Affiliations

¹ Departments of Clinical Blood Sciences and Cardiology, St George's University Hospitals NHS Foundation Trust, London, UK.
² St George's University of London, London, UK.
³ Department of Medical Biochemistry and Pharmacology and Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
⁴ Department of Clinical Science, University of Bergen, Bergen, Norway.
⁵ Department of Laboratory Medicine and Pathology, Hennepin Healthcare/HCMC, Minneapolis, MN, USA.
⁶ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
⁷ Emergency Department, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
⁸ Division of Cardiovascular Sciences, The University of Manchester, Manchester, UK.
⁹ Healthcare Sciences Department, Manchester Metropolitan University, Manchester, UK.
¹⁰ Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Gothenburg, Sweden.
¹¹ Departments of Laboratory Medicine and Pathology and Cardiology, Mayo Clinic, Rochester, MN, USA.
¹² Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
¹³ Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹⁵ Servicio de Bioquímica Clínica, Institut d'Investigacions Biomèdiques Sant Pau, Barcelona, Spain.
¹⁶ Departamento de Bioquímica y Biología Molecular, Universidad Autònoma de Barcelona, Barcelona, Spain.
¹⁷ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

PMID: 36637984
DOI: 10.1515/cclm-2022-1270

Free article

Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)

Paul Collinson et al. Clin Chem Lab Med. 2023.

Free article

. 2023 Jan 16.

doi: 10.1515/cclm-2022-1270. Online ahead of print.

Authors

Affiliations

¹ Departments of Clinical Blood Sciences and Cardiology, St George's University Hospitals NHS Foundation Trust, London, UK.
² St George's University of London, London, UK.
³ Department of Medical Biochemistry and Pharmacology and Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
⁴ Department of Clinical Science, University of Bergen, Bergen, Norway.
⁵ Department of Laboratory Medicine and Pathology, Hennepin Healthcare/HCMC, Minneapolis, MN, USA.
⁶ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
⁷ Emergency Department, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
⁸ Division of Cardiovascular Sciences, The University of Manchester, Manchester, UK.
⁹ Healthcare Sciences Department, Manchester Metropolitan University, Manchester, UK.
¹⁰ Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, Gothenburg, Sweden.
¹¹ Departments of Laboratory Medicine and Pathology and Cardiology, Mayo Clinic, Rochester, MN, USA.
¹² Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
¹³ Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.
¹⁴ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹⁵ Servicio de Bioquímica Clínica, Institut d'Investigacions Biomèdiques Sant Pau, Barcelona, Spain.
¹⁶ Departamento de Bioquímica y Biología Molecular, Universidad Autònoma de Barcelona, Barcelona, Spain.
¹⁷ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

PMID: 36637984
DOI: 10.1515/cclm-2022-1270

Abstract

The International Federation of Clinical Chemistry and Laboarator Medicine (IFCC) Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has provided evidence-based educational resources to aid and improve the understanding of important analytical and clinical aspects of cardiac biomarkers. The present IFCC C-CB educational report focuses on recommendations for appropriate use, analytical performance, and gaps in clinical studies related to the use of cardiac troponin (cTn) by point of care (POC) measurement, often referred to as a point of care testing (POCT). The use of high-sensitivity (hs)-cTn POC devices in accelerated diagnostic protocols used in emergency departments or outpatient clinics investigating acute coronary syndrome has the potential for improved efficacy, reduction of length of stay and reduced costs in the health care system. POCT workflow integration includes location of the instrument, assignment of collection and testing responsibility to (non-lab) staff, instrument maintenance, in-service and recurrent training, quality control, proficiency assessments, discrepant result trapping, and troubleshooting and inventory management.

Keywords: cardiac troponin I; cardiac troponin T; educational recommendations; point of care testing.

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Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)

Affiliations

Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)

Authors

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Abstract

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