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. 2023 Feb 1.
doi: 10.1111/jdi.13984. Online ahead of print.

Which comes first in type 1 diabetes: Autoimmunity or dysglycemia?

Affiliations

Which comes first in type 1 diabetes: Autoimmunity or dysglycemia?

Hiroshi Ikegami. J Diabetes Investig. .

Abstract

A recent study by Warncke et al. suggested that islet autoimmunity is associated with or preceded by insults or changes to the pancreatic islets that impair glucose homeostasis, raising the possibility that β-cell insult occurs first, followed by autoimmunity to islets.

References

REFERENCES

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    1. Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 2015; 38: 1964-1974.
    1. Warncke K, Weiss A, Achenbach P, et al. Elevation in blood glucose before and after the appearance of islet autoantibodies in children. J Clin Invest 2022; 132: e16123.
    1. Ikegami H, Fujisawa T, Ogihara T. Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes. ILAR J 2004; 45: 268-277.