Assessment of executive function in a rodent model of Type 1 diabetes

doi:10.1016/j.bbr.2022.114130

Randomized Controlled Trial

. 2023 Feb 2;437:114130.

doi: 10.1016/j.bbr.2022.114130. Epub 2022 Sep 28.

Assessment of executive function in a rodent model of Type 1 diabetes

Kevin T Murphy¹, Justin Camenzuli¹, Sarah J Myers², Shawn N Whitehead², Nagalingam Rajakumar², C W James Melling³

Affiliations

¹ Exercise Biochemistry Laboratory, School of Kinesiology, Western University, London, ON, Canada.
² Department of Anatomy and Cell Biology, Schulich School of Medicine, Western University, London, ON, Canada.
³ Exercise Biochemistry Laboratory, School of Kinesiology, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine, Western University, London, ON, Canada. Electronic address: jmelling@uwo.ca.

PMID: 36179806
DOI: 10.1016/j.bbr.2022.114130

Randomized Controlled Trial

Assessment of executive function in a rodent model of Type 1 diabetes

Kevin T Murphy et al. Behav Brain Res. 2023.

. 2023 Feb 2;437:114130.

doi: 10.1016/j.bbr.2022.114130. Epub 2022 Sep 28.

Authors

Kevin T Murphy¹, Justin Camenzuli¹, Sarah J Myers², Shawn N Whitehead², Nagalingam Rajakumar², C W James Melling³

Affiliations

¹ Exercise Biochemistry Laboratory, School of Kinesiology, Western University, London, ON, Canada.
² Department of Anatomy and Cell Biology, Schulich School of Medicine, Western University, London, ON, Canada.
³ Exercise Biochemistry Laboratory, School of Kinesiology, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine, Western University, London, ON, Canada. Electronic address: jmelling@uwo.ca.

PMID: 36179806
DOI: 10.1016/j.bbr.2022.114130

Abstract

This study examined the impact of Type 1 Diabetes Mellitus (T1DM) on executive function using a series of operant conditioning-based tasks in rats. Sprague Dawley rats were randomized to either non-diabetic (n = 12; 6 male) or diabetic (n = 14; 6 male) groups. Diabetes was induced using multiple low-dose streptozotocin injections. All diabetic rodents were insulin-treated using subcutaneous insulin pellet implants (9-15 mM). At week 14 of the study, rats were placed on a food restricted diet to induce 5-10 % weight loss. Rodents were familiarized and their set-shifting ability was tested on a series of tasks that required continuous adjustments to novel stimulus-reward paradigms in order to receive food rewards. Results showed no differences in the number of trials, nor number and type of errors made to successfully complete each task between groups. Therefore, we report no differences in executive function, or more specifically set-shifting abilities between non-diabetic and diabetic rodents that receive insulin.

Keywords: Brain; Cognition; Executive function; Insulin; Rat; Reversal learning; Set-shifting; Type 1 diabetes mellitus.

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