Type 1 diabetes: Key drug targets and how they could influence future therapeutics
- PMID: 36744390
- DOI: 10.1080/14728222.2023.2177150
Type 1 diabetes: Key drug targets and how they could influence future therapeutics
Abstract
Introduction: : Despite significant strides made in the management of T1DM, standard management is still insulin analogue therapy. Some non-insulin therapies traditionally reserved for the treatment of T2DM have been explored in caring for patients with T1DM, and pancreas transplant is an option for few. However, T1DM remains a challenging disease to manage, encouraging development of novel pharmacologic agents.
Areas covered: : We retrieved PubMed, Cochrane Library, Scopus, Google Scholar, and ClinicalTrials.gov records to identify studies and articles focused on new pharmacologic advances to treat T1DM.
Expert opinion: : Recent research has focused on new targets of pharmacologic treatment of T1DM. Beta-cell preservation through immunomodulation or inhibiting inflammation hopes to delay or halt the progression of the disease. Beta cell regeneration through islet cell transplant or modification in transcription pathways aim to reverse the disease effects. Multiple other new targets such as glucagon antagonism and glucokinase activation are also in development as a potential adjunctive therapy. These new therapeutic targets offer the hope of reducing the daily burden of diabetes management with eventual insulin discontinuation for many individuals with T1DM.
Keywords: beta cell destruction; beta cell regeneration; glucagon antagonist; glucokinase activator; inceptor; type 1 diabetes.
Similar articles
-
Emerging drugs for the treatment of diabetic nephropathy.Expert Opin Emerg Drugs. 2022 Dec;27(4):417-430. doi: 10.1080/14728214.2022.2155632. Epub 2022 Dec 9. Expert Opin Emerg Drugs. 2022. PMID: 36472144 Review.
-
Human Induced Pluripotent Stem Cells in the Curative Treatment of Diabetes and Potential Impediments Ahead.Adv Exp Med Biol. 2019;1144:25-35. doi: 10.1007/5584_2018_305. Adv Exp Med Biol. 2019. PMID: 30569414 Review.
-
Diabetes type 1: Can it be treated as an autoimmune disorder?Rev Endocr Metab Disord. 2021 Dec;22(4):859-876. doi: 10.1007/s11154-021-09642-4. Epub 2021 Mar 17. Rev Endocr Metab Disord. 2021. PMID: 33730229 Review.
-
Using DPP-4 inhibitors to modulate beta cell function in type 1 diabetes and in the treatment of diabetic kidney disease.Expert Opin Investig Drugs. 2019 Apr;28(4):377-388. doi: 10.1080/13543784.2019.1592156. Epub 2019 Mar 19. Expert Opin Investig Drugs. 2019. PMID: 30848158 Review.
-
Immunotherapies currently in development for the treatment of type 1 diabetes.Expert Opin Investig Drugs. 2015;24(10):1331-41. doi: 10.1517/13543784.2015.1075973. Expert Opin Investig Drugs. 2015. PMID: 26364507 Review.