Press releases > PR Newswire - All News Releases

Cipla EU to Invest EUR 15 million in Ethris, initiating a strategic collaboration

12/29/2022 — investment will facilitate a long-term strategic partnership between Cipla and Ethris for the development of messenger RNA (mRNA)-based therapies and fast-track Cipla's
Press releases > Oregon State University - News

Oregon State University researchers take key step toward new treatment for hereditary blindness

01/11/2023 — instructions to cells for making a particular protein. With the coronavirus vaccines, the mRNA carried by the LNPs instructs cells to make a harmless piece of the virus’ spike
Scientific studies > PubMed Articles

Rheum-CoV-2 Vaccination Case Series.

03/02/2023 — present 5 cases of autoimmune rheumatic disease onset shortly after receiving mRNA vaccination against coronavirus disease 2019 (COVID-19). Methods: We identified 5 patients
Press releases > PR Newswire - All News Releases

Tevard Biosciences announces collaboration with Vertex to develop novel tRNA-based therapies for Duchenne muscular dystrophy

02/28/2023 — tRNA, Enhancer tRNA, and mRNA Amplifier platforms in neurological disorders, heart disease, and muscular dystrophies. For more information, please visit tevard.com . CONTACT: Tevard Biosciences Rebecca Zacks media@tevard.com SOURCE Tevard Biosciences
Scientific studies > PubMed Abstracts

Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles.

03/16/2023 — Free PMC article. Review. Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing. Qiu M, Li Y, Bloomer H, Xu Q. Qiu M, et al. Acc
Scientific studies > PubMed Abstracts

Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial.

12/20/2022 — diagram. Abbreviations: BBB, BNT162b2- BNT162b2- BNT162b2; BBM, BNT162b2-BNT162b2-mRNA-1273; D28, day 28; mRNA, messenger RNA. Figure 2. Level of severe acute respiratory
Scientific studies > PubMed Articles

Protection of Messenger RNA Vaccines Against Hospitalized Coronavirus Disease 2019 in Adults Over the First Year Following Authorization in the United States.

02/09/2023 — Background: Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were authorized in the United States in December 2020. Although vaccine effectiveness (VE) against
Scientific studies > PubMed Abstracts

Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells.

03/23/2023 — ) messenger RNA (mRNA) and microRNA (miRNA) involved in angiogenesis (GeneCards). Paracrine-mediated angiogenic repair capacity of MSC conditioned medium (MSCcm) was assessed
Scientific studies > PubMed Articles

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

02/02/2023 — two-sided Student’s t-test). EMT, epithelial to mesenchymal transition; LOXL2, lysyl oxidase-like protein 2; mRNA, messenger RNA; OSM, oncostatin M; PBMC, peripheral blood
Scientific studies > DOAJ

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

03/08/2023 — manuscript. Here we just focused on three RNA types, mRNA, lncRNA, and circRNA. tRNA was beyond the scope of this study. However, this comment suggests a good direction for our
Scientific studies > PubMed Abstracts

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans.

02/03/2023 — identify messenger RNA (mRNA) rhythms in 46 tissues. Clock transcripts showed conserved timing relationships and tight synchrony across the body. mRNA rhythms varied in breadth
News > Inverse - News

Can a Universal Flu Vaccine Actually Work? mRNA Technology Is a Budding Solution

02/12/2023 — strain. One potential way to do this is with messenger RNA or mRNA. What is a universal influenza vaccine? A universal influenza vaccine is one that does not need to be
Scientific studies > PubMed Abstracts

Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia.

12/23/2022 — , myelodysplastic syndrome or chronic myelomonocytic leukaemia were examined for protein (fluorescence-activated cell sorting) and messenger RNA (mRNA) expression (quantitative
Scientific studies > PubMed Articles

The Race to Develop the Pfizer-BioNTech COVID-19 Vaccine: From the Pharmaceutical Scientists' Perspective.

03/02/2023 — of the BNT162b2 (A)… Fig. 2 Schematic of the BNT162b2 (A) mRNA and (B) lipid nanoparticle. *Lipid attached to… Fig. 2 Schematic of the BNT162b2 (A) mRNA and (B) lipid
Scientific studies > DOAJ

Editorial: Promising roles of functional RNAs in tuberculosis

03/08/2023 — messenger RNA (mRNA), long non-coding RNA (lncRNA), and circular RNA (CircRNA), have been found to be associated with TB progression. With the development of new
Scientific studies > MDPI

The Origin of Translation: Bridging the Nucleotides and Peptides

12/22/2022 — template, transfer RNA as the adaptor, and ribosome RNA as the catalytic core. How tRNA and mRNA formed and how primal peptides were coded in the prebiotic era without
Scientific studies > PubMed Articles

Antibody responses to second doses of COVID-19 vaccination in lung cancer patients undergoing treatment.

03/02/2023 — . - PMC - PubMed Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl
Press releases > Businesswire - Science News

Personalis and Moderna Sign New Agreement to Leverage NeXT Platform™ in Personalized mRNA Cancer Vaccine Clinical Trials

02/03/2023 — biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced the companies have signed a new agreement to continue using the Personalis NeXT
News > New Atlas - News

MicroRNA discovery opens up new target for novel diabetes treatments

02/13/2023 — binding with messenger RNA (mRNA), either marking the mRNA for destruction or subsequent translation. This process is called RNA interference (RNAi) and is an effective tool
News > The Indian Express

Covid-19: Amid growing concerns about their adverse effects, your basic guide to understanding mRNA vaccines

01/10/2023 — peer-reviewed research that re-analysed Pfizer and Moderna trials for mRNA Covid-19 vaccine , has claimed that the messenger RNA (mRNA) vaccine can increase serious adverse
Scientific studies > PubMed Abstracts

Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer.

01/28/2023 — secretion, an underappreciated mechanism that influences the delivery of mRNA lipid nanoparticles. We anticipate that this strategy will enable gene therapies for intractable pancreatic diseases such as diabetes and cancer.
News > Washington Post - business news

Pfizer seeks another ‘moonshot’ with $43 billion cancer deal

03/13/2023 — messenger RNA for its coronavirus vaccine, he said, “What mRNA is for vaccines , ADCs are for cancer.” It is the latest in a series of major deals over the past year, as Pfizer
Scientific studies > PubMed Abstracts

The effect of microRNA on protein variability and gene expression fidelity.

01/26/2023 — AbstractPubMedPMID Abstract Small regulatory RNA molecules such as microRNA modulate gene expression through inhibiting the translation of messenger RNA (mRNA). Such post
News > The Medical News

Comparative study on retinoic acid-inducible gene-I of humans and bats

02/16/2023 — antiviral signaling resulting in virus-responsive promoter transactivation. RIG-I orthologs of humans and R. aegyptiacus could induce IFN-β messenger RNA (mRNA) synthesis
Scientific studies > MDPI

Comparison of COVID-19 Vaccine-Associated Myocarditis and Viral Myocarditis Pathology

02/05/2023 — loss of life and severe disability, justifying the expedited testing and approval of messenger RNA (mRNA) vaccines. While found to be safe and effective, there have been
News > BioPharm International - News

AbbVie and Anima Biotech Partner on Discovery and Development of mRNA Biology Modulators

01/18/2023 — AbbVie and US-based Anima Biotech (Anima) have formed a collaboration to discover and develop messenger RNA (mRNA) biology modulators for three targets across oncology
Scientific studies > MDPI

Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy

03/09/2023 — short time span [ 4 ]. Among them were stand-out vaccines, such as the messenger RNA (mRNA) BNT162b2 vaccine developed by Pfizer [ 5 ]. Given the concerns over their
News > Study Finds - News

Designer babies may hold genetic secret to curing cancer before birth

02/06/2023 — state-of-the-art method to inject sperm into eggs with the latest techniques in messenger RNA (mRNA) sequencing. These are chemicals that carry genetic code from DNA to
News > News-Medical.net - News

MicroRNAs associated with diabetes in human pancreatic islets

02/13/2023 — islet function and T2D pathogenesis are from recent research examining messenger RNA (mRNA) expression within human pancreatic islets. The expression of microRNAs (miRNAs
Scientific studies > PubMed Abstracts

Boosting maternal and neonatal anti-SARS-CoV-2 humoral immunity using a third mRNA vaccine dose.

01/11/2023 — during pregnancy, underscoring the urgent need for relevant data. We aimed to characterize the effect of the third boosting dose of mRNA Pfizer BNT162b2 vaccine in pregnancy
Scientific studies > PubMed Abstracts

Hydrogels for RNA delivery.

03/21/2023 — COVID-19 messenger RNA vaccines. The clinical success of RNA therapy is largely dependent on the use of chemical modification, ligand conjugation or non-viral
News > The Medical News

New solutions to boost Africa’s vaccine production

03/01/2023 — vaccine technology behind Pfizer and Moderna's highly successful COVID-19 jabs, known as messenger RNA (mRNA), to replicate existing vaccines and drive research into the
Press releases > Businesswire - Health News

Arcturus Therapeutics to Present at the 41st Annual J.P. Morgan Healthcare Conference

12/19/2022 — expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs
News > Medical Xpress

Bivalent COVID vaccines have now been in use for a few months—here's how they're stacking up against omicron

01/11/2023 — omicron. mRNA vaccines: an update Both Moderna and Pfizer/BioNTech have updated their mRNA vaccines to provide broader protection. These vaccines contain small chains of
Scientific studies > PubMed Abstracts

Antibody and T-Cell Responses 6 Months After Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant.

02/09/2023 — transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial. Kho MML, Messchendorp AL, Frölke SC, Imhof C, Koomen VJ
News > Medical Xpress

What will it take to boost Africa's vaccine production?

03/01/2023 — yet. The hubs are expected to employ the breakthrough vaccine technology behind Pfizer and Moderna's highly successful COVID-19 jabs, known as messenger RNA (mRNA), to
News > Advanced Science News - News

siRNA therapies delivered with oral nanocapsules

02/27/2023 — translation from messenger RNA (mRNA). siRNA molecules are unique in that they “stick” to mRNA molecules, hiding them from the cell’s machinery when necessary, and thus
Scientific studies > DOAJ

YB1 participated in regulating mitochondrial activity through RNA replacement

03/24/2023 — inhibited OXPHOS gene translation. (A) The influence of YB1 knockdown on mitochondrial oxidative phosphorylation gene (NDUFA9 and SDHB) expressions at the mRNA level. n = 3
Scientific studies > PubMed Abstracts

A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress.

02/23/2023 — , giving rise to an RNA that functions both as RIEP messenger RNA (mRNA) and as PAPAS lncRNA, as well as containing the promoter sequences responsible for rRNA synthesis by
News > Business Recorder - Pakistan

Davos 2023: Moderna CEO in talks with China to supply COVID vaccines

01/18/2023 — regime. As regards cancer treatments, Moderna has been working with Merck on an experimental vaccine against melanoma based on the mRNA technology used in successful
News > Phys.org - News

Poisons are a potent tool for murder in fiction: A toxicologist explains how some dangerous chemicals kill

03/22/2023 — inhibit the activity of a specific enzyme critical for the production of messenger RNA , or mRNA, a molecule essential to protein synthesis in cells. Because ingested
Scientific studies > PubMed Articles

Mechanism of astragalus injection to relieve symptoms of preeclampsia rat model by inhibiting MMP-9/sFlt-1/TNF-α.

03/02/2023 — mass in the MG group was lower than in the CG and AG groups (P < .05). The messenger RNA (mRNA) and protein levels of sFlt-1, NFAT-5 and NF-κB, as well as ROS activity
Scientific studies > PubMed Abstracts

Urine as liquid gold: the transcriptional landscape of acute rejection defined by urinary cell mRNA profiling of kidney allograft recipients.

02/11/2023 — . Towards a patient friendly protocol for urinary cell messenger RNA (mRNA) profiling, we developed a filtration-based protocol for the initial processing of urine at home and
Scientific studies > PubMed Articles

Omentin-1 Levels and Outcomes in Incident Peritoneal Dialysis Patients.

03/02/2023 — PD patients. Predictors: Plasma omentin-1 level, adipose tissue omentin-1 messenger RNA (mRNA) expression. Outcomes: Patient survival, technique survival, hospital
Scientific studies > PubMed Abstracts

Analyzing the Association of Visceral Adipose Tissue Growth Differentiation Factor-15 and MicroRNA in Type 2 Diabetes Mellitus.

03/16/2023 — -diabetic patients (P<0.001). Target prediction revealed a microRNA (miRNA)-messenger RNA (mRNA) regulatory network, transcription factors, and functional enrichment for the
Patent filings > APPFT - Patent Applications


12/15/2022 — functional sequence, so that messenger RNA (mRNA) vaccine is optimized to be a self-amplifying messenger RNA (SAM) vaccine. r /> >4. The messenger ribonucleic acid
Press releases > Businesswire - Science News

Ethris Announces Collaboration with DIOSynVax and CEPI to Develop a Broadly Protective mRNA Vaccine Against Betacoronaviruses

12/21/2022 — Innovations (CEPI) MUNICH--( BUSINESS WIRE )-- Ethris GmbH , a leading biotechnology company pioneering next-generation messenger RNA (mRNA) therapeutics and vaccines, announced
News > Biopharma Dive - News

Moderna inks another gene editing deal

02/22/2023 — Wednesday , will pair the former’s mRNA platform with the latter’s “suite of proprietary gene editing technologies,” which includes DNA base editors and RGNs, or RNA-guided
Scientific studies > DOAJ

Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation

03/16/2023 — ) vaccine BNT162b2 was the first ever modified RNA-based (mRNA) vaccine that received U.S. Food and Drug Administration (FDA) approval for use. Despite the satisfactory
Press releases > Healio - News

Intrarenal podocalyxin level may predict dialysis-free survival in diabetic kidney disease

01/24/2023 — (mRNA), it did not predict the progression of DKD in patients. Researchers observed a modest correlation between intrarenal podocalyxin levels and its urinary mRNA and
Press releases > Healio - News

Q&A: An optimistic view of a ‘failed’ HIV vaccine trial

02/24/2023 — a sense of the accomplishment of American and worldwide science. Healio: Where does HIV mRNA vaccine research stand now? Corey: Messenger RNA is a tool, and it’s a tool
Scientific studies > PubMed Abstracts

Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification.

02/11/2023 — position of tRNA, which is able to base pair with the 3'-end codon on mRNA, is usually modified to influence many aspects of decoding properties during translation
Scientific studies > PubMed Abstracts

Differentially expressed messenger RNA/proteins can distinguish teratoma from necrosis in postchemotherapy retroperitoneal lymph node dissection (pcRPLND) tissue.

12/12/2022 — viable GCT. The purpose of this study was to explore messenger RNA (mRNA) and proteins to distinguish TER from NEC in pcRPLND tissue. Methods: The discovery cohort
Scientific studies > MDPI

The microRNA Lifecycle in Health and Cancer

11/23/2022 — based on complementarity between miRNA and messenger RNA (mRNA), translation is repressed or the mRNA is degraded. Binding of the miRISC to the target mRNA can induces
News > Lab Manager - News

New Research Promises Potential Treatment for Hereditary Blindness

01/16/2023 — nanoparticles (LNPs) and messenger RNA, the same technique upon which mRNA COVID-19 vaccines are built. In a study published in Science Advances , the authors describe the
News > Trib Live

Moderna, Cirrus Logic are Balance Sheet Powerhouses

02/19/2023 — Administration for emergency use. The company’s name reflects its core technology, involving messenger RNA, or mRNA for short. The company believes that mRNA, wrapped in lipids
Scientific studies > DOAJ

N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms

03/15/2023 — chromosome ( 20 ). Interestingly, YTHDC2 promotes mRNA translation with a concomitant decrease in mRNA abundance and has ATPase and 3’ to 5’ RNA helicase activities ( 13
Press releases > Businesswire - Health News

Recode Therapeutics Expands Leadership Team with Appointment of April Loui as Senior Vice President of Quality and CMC Regulatory Affairs

02/01/2023 — Therapeutics ReCode Therapeutics is a genetic medicines company using superior delivery to power the next wave of messenger RNA (mRNA) and gene correction therapeutics. ReCode’s
News > MedCity News - News

Merck Vaccines Pipeline Gets Boost Via Deal for Opko Candidate for Epstein-Barr

03/08/2023 — development. The most advanced of the two, mRNA-1189, addresses the viral proteins gp220, gp42, and the gH/gL protein complex. That vaccine candidate, which carries four mRNAs
Scientific studies > PubMed Abstracts

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts.

12/19/2022 — mRNA delivery systems targeting fibrotic diseases. Keywords: CRISPR/Cas9; gene edition; high-throughput screening; messenger RNA; polymeric nanoparticles. © 2022 The
Scientific studies > PubMed Abstracts

Messenger RNA in lipid nanoparticles rescues HEK 293 cells from lipid-induced mitochondrial dysfunction as studied by real time pulse chase NMR, RTPC-NMR, spectroscopy.

12/25/2022 — ). - DOI Kariko, K., Whitehead, K. & van der Meel, R. What does the success of mRNA vaccines tell us about the future of biological therapeutics?. Cell Syst. 12, 757
Scientific studies > PubMed Articles

The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice.

02/02/2023 — macrophage; ELISA, enzyme-linked immunoassay; IL, interleukin; LPS, lipopolysaccharide; mRNA, messenger RNA; MyD88, myeloid differentiation factor 88; PCR, polymerase chain
Scientific studies > PubMed Abstracts

A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway.

01/14/2023 — /sciadv.ade2828 Item in Clipboard CiteCollectionsDisplay options Display options Format AbstractPubMedPMID Abstract Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been
Scientific studies > PubMed Articles

Off-label prescription of BNT162b2 mRNA COVID-19 vaccine to <5-year-old children in the European Union.

02/02/2023 — prescription of BNT162b2 mRNA COVID-19 vaccine to <5-year-old children in the European Union Rafael Dal-Ré  1 , Cristina Calvo  2   3 , Olaf Neth  4   5 Affiliations Expand
News > The Medical News

Research uncovers a new way to boost the effectiveness of RNA therapies

12/20/2022 — naturally stabilize the heartbeat." In the latest research study, Cingolani and team harnessed the same modified messenger RNA (mRNA) technology used in creating the Pfizer and
Scientific studies > PubMed Abstracts

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women.

02/16/2023 — inflammatory, coagulation and metabolic parameters in PCOS are less robust. Therefore in this study, we investigated and compared the messenger RNA (mRNA) expression profiles of
Scientific studies > PubMed Articles

Structure of the Caenorhabditis elegans m6A methyltransferase METT10 that regulates SAM homeostasis.

03/22/2023 — (MAT2A-hp1–6) pre-mRNAs (31). (B) Secondary structures of 3'-UTR hairpin RNA (MAT2A-hp1) of human MAT2A pre-mRNA (left) and C. elegans sams hairpin RNA spanning intron 2
Scientific studies > DOAJ

Gross Hematuria following SARS-CoV-2 Vaccination

03/13/2023 — , healthcare systems are still challenged by uncertainties surrounding currently available preventive measures [ 1]. In December 2020, two messenger RNA (mRNA) COVID-19
Scientific studies > PubMed Abstracts

Surviving and adapting to stress: Translational control and the integrated stress response.

03/22/2023 — eIF2•GTP required to deliver initiator tRNA to ribosomes. While bulk mRNA translation can be sharply lowered by heightened phosphorylation of eIF2α, there are other gene
Scientific studies > MDPI

Targeted Demethylation of the TGFβ1 mRNA Promotes Myoblast Proliferation via Activating the SMAD2 Signaling Pathway

03/24/2023 — that appropriate endogenous TGFβ1 may be crucial for myoblast proliferation. The RNA modification m6A is a reversible process that regulates gene expression at the mRNA
Scientific studies > PubMed Articles

Risk Factors for Reinfection with SARS-CoV-2 Omicron Variant among Previously Infected Frontline Workers.

03/02/2023 — -CoV-2 infection among health-care workers with and without mRNA vaccination: a test-negative case-control study. Carazo S, Skowronski DM, Brisson M, Barkati S, Sauvageau
Clinical trials > Clinical Trials - New studies

Association Between PM2.5 Exposure and Ferroptosis in Seizures Patients

03/07/2023 — used to compare the lipid reactive oxygen species level in two groups Real-Time Quantitative PCR(RT-qPCR) was used to compare messenger RNA (mRNA) expression of the Nrf2
News > GenomeWeb - News

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

11/28/2022 — messenger RNA (mRNA) degradation rates in humans and mice. Using transcriptome-wide mRNA half-life patterns found in dozens of human or mouse datasets, the team used available
Scientific studies > PubMed Articles

Imaging characteristics of myocarditis after mRNA-based COVID-19 vaccination: a meta-analysis.

02/02/2023 — Imaging characteristics of myocarditis after mRNA-based COVID-19 vaccination: a meta-analysis Shingo Kato et al. ESC Heart Fail. 2023 Feb. Free PMC article Show details Display
News > Toronto Sun - Canada

Experimental skin cancer vaccine shows promising early results

12/13/2022 — significant. “Today’s results are highly encouraging for the field of cancer treatment,” Stéphane Bancel, Moderna’s chief executive officer, said in a news release. “mRNA
News > ACCESSWIRE - News

CureVac Announces Closing of $250 million Follow-on Public Offering of Common Shares

02/10/2023 — CureVac CureVac (NASDAQ:CVAC) is a global biopharmaceutical company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing
News > Manila Bulletin - Philippines

Moderna, Merck see positive results from skin cancer vaccine

12/14/2022 — Executive Officer Stephane Bancel, said in a statement. “mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA
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