12/15/2022 — , a gene may encode a protein-coding RNA essential for protein/peptide synthesis, such as messenger RNA (mRNA) and its RNA precursors as well as derivatives. In some cases

02/20/2023 — ], selection forces [ 70 ], TpA having mRNA destabilizing effect [ 62 ], higher susceptibility of UpA to cytoplasmic RNase [ 71 ] and evading interferon-inducible protein ZAP and

02/01/2023 — ) is a global biopharmaceutical company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing, optimizing, and manufacturing

12/30/2022 — show changes in PTM profiles of proteins involved in messenger RNA processing and neuronal projections and synaptic processes B Villadsen  1   2 , C Thygesen  1   2

02/09/2023 — . Abbreviations: COVID-19, coronavirus disease 2019; mRNA, messenger RNA; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Figure 1. Distribution and time to onset

02/15/2023 — public health need. VERVE-101 is designed to permanently lower low-density lipoprotein cholesterol VERVE-101 consists of an adenine base editor (ABE) messenger RNA (licensed

02/23/2023 — vaccines, such as messenger RNA (mRNA), that provide scalability and can be quickly adapted as new variants appear. DNA vaccines are also nucleic acid vaccines. Currently, 250

01/15/2023 — , tRNAs were removed from the primary transcripts, leaving messenger RNA (mRNA) and rRNA transcripts. As a supplement to this model, the “reverse cleavage” model in

03/02/2023 — . Only one case of new development of mild chronic GVHD was recorded. Conclusion: Messenger RNA COVID-19 vaccines induce humoral responses in allo-HSCT recipients and

12/02/2022 — "Heterologous adenovirus-vector/messenger RNA regimen, humoral response and liver transplant recipients" Pathum Sookaromdee  1 , Viroj Wiwanitkit  2 Affiliations Expand

01/10/2023 — Therapeutics is a genetic medicines company using superior delivery to power the next wave of messenger RNA (mRNA) and gene correction therapeutics. ReCode’s selective organ

12/13/2022 — decades with only limited success, not least because they’re hard to manufacture on a large scale. Moderna’s messenger RNA technology is more flexible than many older

11/30/2022 — .; Rottman, F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl. Acad. Sci. USA 1974 , 71, 3971–3975. [ Google Scholar

02/14/2023 — interest. Similar articles Molecular mechanism of reward treatment ameliorating chronic stress-induced depressive-like behavior assessed by sequencing miRNA and mRNA in

02/07/2023 — ) is a global biopharmaceutical company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing, optimizing, and manufacturing

02/07/2023 — future molecular methods as they pertain to DNA and primarily to messenger RNA degradation for the estimation of the PMI, as well as the use of RNA in aging wounds, aging

03/01/2023 — ), CCAAT/enhancer-binding protein homologous protein (CHOP), and X-box-binding protein 1 compared to the placebo group, though the reduction in the messenger RNA (mRNA

01/24/2023 — efficacy and safety of messenger RNA (mRNA) COVID-19 vaccines in children aged 5 to 11 years has been emerging. Collecting these data will inform clinicians, families, and

12/14/2022 — ? Weissman: In an mRNA vaccine, the mRNA acts as a kind of middleman. In our cells, DNA contains all the codes for the proteins we need to live. The messenger RNA makes a

01/24/2023 — higher and less dependent on the GC content parameters in the IVT-Plasmids messenger RNA (mRNA) selection free RNA-Seq sample (control) than in the other RNA-Seq samples

02/03/2023 — individually account for 53% and 20% of variance in translation, respectively, and show conclusively that, contrary to a common hypothesis, tRNA abundance does not explain

02/17/2023 — ;1829(3-4):376-84. doi: 10.1016/j.bbagrm.2012.11.004. Epub 2012 Nov 28. Biochim Biophys Acta. 2013. PMID: 23201230 Review. Regulation of tRNA synthesis by the general

03/15/2023 — on the tumor tissues (RCC) and their matching adjacent normal tissues (Normal). Subsequently, we applied differential analysis of messenger RNA (mRNA), miRNA, lncRNA, and

01/23/2023 — messenger RNA (mRNA) — which delivers its genetic blueprints to the cell’s protein-making machinery. Now researchers at MIT and the Howard Hughes Medical Institute (HHMI

02/09/2023 — = 0.0009; IL-10, P = 0.0007; IL-13, P = 0.0008) and the mRNA expression of M2 markers (TGF-β1, P = 0.0016; ARG1, P = 0.0083). Flow cytometry showed that 5'tiRNA-Gly

11/23/2022 — : journals.permissions@oup.com. Similar articles Circadian control of messenger RNA stability. Association with a sequence-specific messenger RNA decay pathway. Lidder P, Gutiérrez RA

01/04/2023 — -old company was able to swiftly develop an effective coronavirus vaccine within months of the onset of the pandemic. Pfizer and partner BioNTech also used mRNA technology

03/16/2023 — review. Front. Nutr. 2021 , 8, 685165. [ Google Scholar ] [ CrossRef ] Yu, Y.C.; Han, J.M.; Kim, S. Aminoacyl-tRNA synthetases and amino acid signaling. Biochim. Biophys

01/30/2023 — outstanding questions about meiosis. We conducted a meiotic stage-specific analysis of messenger RNA (mRNA), small non-coding RNA (sncRNA) and long intervening/intergenic non

03/17/2023 — vaccine for preventing coronavirus disease 2019 (COVID-19) in people from the age of 18 years. BNT162b2 contains tozinameran, a messenger RNA (mRNA) molecule with

03/04/2023 — significant decrease in cell viability in SERPINE1-si- lenced cells compared with the control cells. mRNA, messenger RNA; GAPDH, glyceral- dehyde-3-phosphate dehydrogenase; NC

01/18/2023 — its experimental messenger RNA vaccine for respiratory syncytial virus (RSV) was 83.7% effective in a late-stage trial at preventing at least two symptoms, such as cough

01/19/2023 — continue to look into the mechanism by which this polarized expression of tRNAs occurs. “If we can figure out how this tRNA polarization happens,” says Tavazoie, “we could perhaps develop an approach to controlling metastatic disease.” Keywords:

03/14/2023 — , Avery RK, Tobian AAR, Massie AB, Segev DL, et al. Immunogenicity of a single dose of SARS-CoV-2 messenger RNA vaccine in solid organ transplant recipients. JAMA (2021) 325

01/05/2023 — “DNA.fwdarw.(transcription).fwdarw.mRNA (messenger RNA).fwdarw.(translation) protein”. For example. RNA-Seq (RNA sequencing) using a next-generation sequencer can reveal the

03/02/2023 — apoptosis. Moreover, k-Ras, a unique oncogene, was confirmed as a direct target of miR-143-3p, and k-Ras messenger RNA (mRNA) expression was increased in WT tissues and

01/02/2023 — . - PMC - PubMed Show all 22 references MeSH terms Nonsense Mediated mRNA Decay* Actions Search in PubMed Search in MeSH Add to Search Protein Biosynthesis

01/16/2023 — ( Nanowerk Spotlight ) COVID-19 is a game changer for both nanomedicine and nucleic acid-based vaccines. Just two years ago, there were no licensed messenger RNA (mRNA

03/02/2023 — . 2017. PMID: 27465259 Review. Mechanistic insights into precursor messenger RNA splicing by the spliceosome. Shi Y. Shi Y. Nat Rev Mol Cell Biol. 2017 Nov;18(11):655-670

02/10/2023 — which underscores that the method really does capture the intermediate pep-tRNA pool during translation. ", says Prof. Taguchi when quizzed on the significance of their

03/15/2023 — .74255. Elife. 2022. PMID: 35357307 Free PMC article. Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex. Khan K, Long B

12/07/2022 — extraordinary conformational stability [ 12 ]. Within the cell, transfer RNA (tRNA) is the main target of ranpirnase leaving ribosomal RNA (rRNA) and messenger RNA (mRNA

01/14/2023 — CiteCollectionsDisplay options Display options Format AbstractPubMedPMID Abstract Eukaryotic messenger RNA (mRNA) typically contains a methylated guanosine (m7G) cap, which

01/28/2023 — -specific genes at messenger RNA (mRNA) on days 7 and 14 of differentiation using quantitative real-time PCR. In addition, Klotho status at protein level was evaluated by

12/20/2022 — Messenger RNA Vaccine Induces Airway Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Naive and Recovered Coronavirus Disease 2019 Subjects Emanuela Martinuzzi  1

01/06/2023 — , experts say. The shots from Pfizer and Moderna use messenger RNA, or mRNA, to instruct the body to create a protein from the coronavirus. The Johnson & Johnson vaccine

11/29/2022 — polymeric formulations for inhalable messenger RNA delivery to the lung Laura Rotolo #  1 , Daryll Vanover #  1 , Nicholas C Bruno #  2 , Hannah E Peck  1 , Chiara Zurla

12/14/2022 — Background: Association between messenger RNA (mRNA) COVID-19 vaccines and myocarditis has aroused public concern over vaccine safety. Objectives: The goal of this study was

02/08/2023 — the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing, optimizing, and manufacturing this versatile biological molecule for

02/02/2023 — independent of the type of administered SARS-CoV-2-vaccine (p for subgroup differences = 0.7 for messenger RNA (mRNA), inactivated virus, and adenovector-based vaccines

01/12/2023 — expedite time to approval and commercial availability,” she explained. mRNA vaccines mRNA stands for “messenger RNA,” and it works by translating “messages” from DNA to

03/19/2023 — used for the reverse-transcription (RT) PCR were as follows: 5;-GGTGTGCTCAACAGCCTTATC-3; and 5;-TTATGGCAACCTTGCTTATG-3; for detecting rat CD36 messenger RNA (mRNA), 5

03/17/2023 — verify the binding with Kanamycin B in vitro. Kanamycin B and ibsC mRNA was analysed by chemical probing. Conclusions: The results will provide biochemical evidence and

02/10/2023 — CW, Kuo KC, Waalkes TP, Borek E. tRNA breakdown products as markers for cancer. Cancer. 1979;44:2120–3. Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, et al. PANDORA

01/19/2023 — to significantly interfere with the binding of messenger RNA (mRNA) to YB-1 in cells. One of our leads is an FDA-approved poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor

03/02/2023 — precursor miR-29a-3p, DGCR8 The double-stranded RNA-binding protein, mRNA Messenger RNA, 3’UTRs 3’Untranslated regions, RISC MiRNA-induced silencing complex Fig. 3 miR-29a-3p

02/15/2023 — reverse transcriptase polymerase chain reaction was performed to measure miR-1285-5p, miR-140-5p, IL-20, and high-mobility group box 1 (HMGB1) messenger RNA (mRNA) expression

01/12/2023 — Cancer Centre and their research team made the Québec Science list for their discovery of the key element in the control of messenger ribonucleic acid (Messenger RNA or

02/02/2023 — : Dadas las justificaciones patogénicas, se debe considerar la asociación entre lupus eritematoso sistémico (LES) y miocarditis. Keywords: BNT162B2 messenger RNA; COVID-19

12/20/2022 — Clin Infect Dis Actions Search in PubMed Search in NLM Catalog Add to Search . 2022 Dec 19;75(12):2186-2192. doi: 10.1093/cid/ciac325. Effectiveness of Messenger RNA

01/27/2023 — .; Toropygin, I.Y.; Shuvalov, A.; Egorova, T.; Alkalaeva, E. Recognition of 3′ nucleotide context and stop codon readthrough are determined during mRNA translation

02/05/2023 — , 459–461. [ Google Scholar ] [ CrossRef ] Sugihara, K.; Kono, M.; Tanito, M. Branch Retinal Vein Occlusion after Messenger RNA-Based COVID-19 Vaccine. Case Rep. Ophthalmol

02/21/2023 — RNAi therapeutic platform, function upstream of today’s medicines by potently silencing messenger RNA (mRNA) – the genetic precursors – that encode for disease-causing or

10/07/2022 — , referred to as a double helix. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. The mRNA in the

01/17/2023 — unknown. Memory performance of APP/PS1 mice was assessed by Morris water maze test. Expression of circLPAR1 and indicated messenger RNA (mRNA) in mouse brain tissues or/and SH

01/08/2023 — , Salathia NS, Brewer JB et al (2020) Noninvasive characterization of Alzheimer’s disease by circulating, cell-free messenger RNA next-generation sequencing. Sci Adv. https

03/07/2023 — plasmids is rising dramatically as large numbers of messenger RNA (mRNA) vaccines and viral-vector-based therapeutics advance through clinical trials toward approval and

12/02/2022 — an HFD. Values represent mean ± SEM. HFD, high‐fat diet; mRNA, messenger RNA; PHB1, prohibitin‐1. **p < 0.01 FIGURE 2 Adipocyte‐specific deletion of Phb1 reduces… FIGURE

02/23/2023 — healthcare professional. GIVLAARI works by specifically reducing elevated levels of ALAS1 messenger RNA (mRNA), leading to reduction of toxins associated with attacks and

01/12/2023 — diversity and provide structural novelty in mRNA display libraries through a heterocycle forming macrocyclization.

11/28/2022 — & Co-Founder, Strand Therapeutics. “The idea behind Strand and programmable mRNA in cancer, is to stimulate an immune response against the tumor using messenger RNA. With

01/02/2023 — eosinophil-rich linear IgA bullous disease (LABD) following the administration of a messenger RNA COVID-19 booster vaccine. A 66-year-old man presented to the emergency

02/16/2023 — Receipt of the BNT162b2 Messenger RNA COVID-19 Vaccine During the Second Trimester of Pregnancy. Kugelman N, Nahshon C, Shaked-Mishan P, Cohen N, Sher ML, Gruber M, Marom

02/02/2023 — messenger RNA COVID-19 vaccine was evaluated in 44 CLL patients comprising 20 treatment-naïve, 14 under treatment with ibrutinib and 10 in follow-up after completion of

02/14/2023 — : 10.1111/imr.13088. Epub 2022 Jun 11. Immunol Rev. 2022. PMID: 35689434 Free PMC article. Review. Immunogenicity and clinical features relating to BNT162b2 messenger RNA

01/18/2023 — DNA methylation writers DNMT1, DNMT3A and DNMT3B messenger RNA (mRNA) and a decrease in the reader UHRF1 mRNA in AD samples across three brain regions whilst the DNA

03/14/2023 — December 2020, the IMH launched a national campaign to vaccinate the population with 2 doses of BNT162b2 (Pfizer-BioNTech) messenger RNA (mRNA) anti-SARS-CoV-2 vaccine, given 3

03/03/2023 — likely to function as an miR sponge and to positively regulate target mRNA translation. circRNAs containing binding motifs for RBPs might sponge these proteins and regulate

03/02/2023 — (messenger RNA [mRNA]-1273 [Moderna, Cambridge, Massachusetts, USA]; n = 139) vaccination were asked to participate when receiving their second dose. Reactogenicity was