Clinical trials > Clinical Trials - New studies

Efficacy and Safety of Android Artificial Pancreas System in Adult Patients With Type 1 Diabetes Mellitus in China

02/14/2023 — Yat-Sen University: Type 1 diabetes mellitus; Artificial pancreas system; Do-it-yourself artificial pancreas system; Automated insulin delivery
Scientific studies > PubMed Articles

Fulminant type 1 diabetes developed after influenza split vaccination.

05/05/2023 — diabetes (FT1D) is a subtype of diabetes characterized by rapid progression of β-cell destruction, hyperglycemia, and diabetic ketoacidosis (DKA). The pathogenesis of this
Clinical trials > Clinical Trials - New studies

Comparison of Insulin Glargine and Regular Insulin Versus NPH and Regular Insulin in the Treatment of T1DM

02/02/2023 — Regular Insulin in Type 1 Diabetes in Children Drug: Glargine and regular insulin versus NPH and regular insulin Phase 4 Detailed Description: Diagnosed patients with Type-1
Clinical trials > Clinical Trials - Study Results

The International Diabetes Closed Loop (iDCL) Trial: Protocol 4

12/02/2022 — or Cleared by U.S. FDA: Yes Keywords provided by Sansum Diabetes Research Institute: Artificial Pancreas Automated Insulin Delivery Closed Loop Control
Scientific studies > PubMed Abstracts

A mechanistic modeling platform of SGLT2 inhibition: Implications for type 1 diabetes.

03/14/2023 — dysfunction of the insulin-producing beta-cells in the pancreas. Dapagliflozin, an inhibitor of renal glucose reabsorption, has the potential to improve often suboptimal glycemic
Scientific studies > DOAJ

Sleep architecture in children with Diabetes Mellitus Type 1

02/28/2023 — problems and disruption can affect insulin sensitivity and glucose regulation. [1]. Sleep Disordered Breathing (SDB) has primarily been studied in adults with Type 2
News > GenomeWeb - News

Study Links Gut Microbiome to Type 1 Diabetes

10/14/2022 — type 1 diabetes. Microbiome dysbiosis is a known feature of diabetes, but how microbial products influence insulin production is not well understood. To better understand
News > New Atlas News

Sugar-powered teabag-like implant successfully manages type 1 diabetes

03/29/2023 — powered by glucose senses excess blood sugar, it powers up. This then stimulates the beta cells to produce and secrete insulin. As blood sugar levels dip, it trips a
News > The Medical News

Bionic pancreas effective at maintaining blood glucose levels in people with type 1 diabetes

10/13/2022 — Medicine . Automated insulin delivery systems, also called artificial pancreas or closed-loop control systems, track a person's blood glucose levels using a continuous glucose
Scientific studies > MDPI

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

02/04/2023 — delivery and glucose variability throughout the menstrual cycle on closed loop control for women with type 1 diabetes. Diabetes Technol. Ther. 2022 , 24, 357–361. [ Google
News > The Arizona Republic (AZCentral) - Nation News

FDA approves first treatment that delays type 1 diabetes. Experts call it 'game changing.'

11/18/2022 — pancreas, according to the British Diabetic Association, or Diabetes UK. This is different from type 2 diabetes, which is caused when the body makes less insulin or becomes
Press releases > McGill University - Press releases

Children in Quebec are not diagnosed early enough with type 1 diabetes

01/12/2023 — . It occurs when the pancreas stops producing insulin, an important hormone that helps your body control the level of sugar in the blood. Diabetic ketoacidosis (DKA) is a
Clinical trials > Clinical Trials - Study Results

Feasibility of a Decision Support System to Reduce Glucose Variability in Subject With T1DM

03/23/2023 — ; 1-2 basal insulin injections per day, consistent in timing and amount. A. Historical criteria for documented hyperglycemia (at least 1 must be met): i. Fasting glucose
News > Medical Xpress

Type 1 diabetes: First clinical trial of GABA/GAD in newly diagnosed, very young children

02/22/2023 — cells take up glucose from the blood when glucose levels are high. In contrast, glucagon helps the liver release glucose into the bloodstream when glucose levels are low
Press releases > Healio - News

Empagliflozin as adjunctive therapy improves time in range in type 1 diabetes

03/02/2023 — inhibitors as an adjunct to insulin therapy have been shown to reduce HbA1c in type 1 diabetes. The caveat is there is risk for diabetic ketoacidosis, particularly euglycemic
Scientific studies > DOAJ

Continuous Glucose Monitoring-Derived Metrics and Capillary Vessel Density in Subjects with Type 1 Diabetes without Diabetic Retinopathy

04/23/2023 — )-derived glucose metrics and OCTA parameters in young adult patients with type 1 diabetes without diabetic retinopathy (DR). Inclusion criteria were years, diagnosis of type
News > The Hindu - India

Children with Type 1 diabetes hope for a sweeter ‘Mittayi’

02/16/2023 — children from Mittayi. However, Type 1 diabetes has no cure, the society points out. It can only be managed by controlling sugar levels using insulin, diet, and lifestyle
Scientific studies > PubMed Abstracts

Clinical and experimental treatment of type 1 diabetes.

12/16/2022 — Display options Format AbstractPubMedPMID Abstract Type 1 diabetes (T1D) is an autoimmune disease resulting in the destruction of the insulin-producing pancreatic beta cells
Scientific studies > PubMed Abstracts

Pancreatic sympathetic innervation disturbance in type 1 diabetes.

05/02/2023 — terms Diabetes Mellitus, Type 1* Actions Search in PubMed Search in MeSH Add to Search Humans Actions Search in PubMed Search in MeSH Add to Search Insulin Actions
Press releases > National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Diseases - Press Releases

Testing a Next-generation Artificial Pancreas Device for Managing Type 1 Diabetes

11/22/2022 — glucose (hypoglycemia). These results are important because glucose management is extremely challenging during adolescence and young adulthood. Artificial pancreas technology
News > Pharmacy Times - News

Albuminuria is More Prevalent in Type 1 Diabetes

12/19/2022 — Diabetes mellitus (DM) is a chronic metabolic disorder affecting up to 12% of individuals in the United States. Consisting of type 2 diabetes (T2DM) and type 1 diabetes
News > Pharmacy Times - News

AI Could Improve Blood Sugar Management in Type 1 Diabetes

01/17/2023 — diabetes in the United States. People with type 1 diabetes require insulin to help them regulate blood sugar levels. Uncontrolled, people with type 1 diabetes are at risk of
Securities filings > Edgar - 8-K

8-K - vTv Therapeutics Inc. (0001641489) (Filer)

01/06/2023 — Activator to Reach Phase 3 Pancreas Effect Lowers threshold for insulin production Triggers storage of glucose as glycogen Result Rapid decline in blood sugar levels: Induces
Scientific studies > PubMed Abstracts

Clinical and biochemical profile of childhood-adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians.

01/27/2023 — biochemical profile of childhood-adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians Viswanathan Mohan  1 , Ganesan Uma Sankari  2
Clinical trials > Clinical Trials - New studies

Self-Management in Young Adults With Type 1 Diabetes 2023

04/21/2023 — -regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Diabetes Mellitus Diabetes Mellitus, Type 1 Glucose Metabolism Disorders
Press releases > Georgia Institute of Technology - News

New Startup Develops Potential Cure for Type 1 Diabetes

11/04/2022 — , so when we transplant it with cells, it trains the immune system to accept the graft as self and not to reject.” The Insulin Issue Type 1 diabetes is an autoimmune
News > SciTechDaily: Atomic Physics news

Could COVID-19 Cause Type 1 Diabetes?

04/20/2023 — increase in the incidence of pediatric diabetes temporary? In the study, the incidence of type 1 diabetes in Finns under 15 years of age was compared to three preceding
Clinical trials > Clinical Trials - New studies

Teplizumab in Pediatric Stage 2 Type 1 Diabetes

03/07/2023 — Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Autoimmune Diseases Immune System Diseases To Top
Scientific studies > PubMed Abstracts

Glycemic Risk Index Profiles and Predictors Among Diverse Adults With Type 1 Diabetes.

03/31/2023 — on CGM or automated insulin delivery systems. Keywords: automated insulin delivery systems; continuous glucose monitoring; diabetes self-management; glycemic risk index; health inequities; type 1 diabetes.
News > Healio news

Time in range similar with fast-acting vs. standard insulin for young kids with diabetes

05/08/2023 — hypoglycemia, time spent in hyperglycemia or glucose variability. Children received slightly more insulin when using fast-acting insulin aspart compared with standard insulin
Scientific studies > MDPI

Contribution of Retrotransposons to the Pathogenesis of Type 1 Diabetes and Challenges in Analysis Methods

02/04/2023 — polyuria, along with overt hyperglycemia [ 1 , 2 ]. The features most useful in discrimination of type 1 diabetes include younger age at diagnosis (<35 years) with lower
News > Scienmag - News

nPOD honors Estefania Quesada Masachs for type 1 diabetes discoveries

04/17/2023 — kill insulin-producing beta cells in the pancreas and cause type 1 diabetes. She also studies the local pancreatic environment and the behavior of insulin-producing
News > The Medical News

A gloomy outlook for type 1 diabetes in children and adolescents by 2050

01/06/2023 — /PIIS2213-8587(22)00276-5/fulltext Tags: Adolescents , Biomarker , Blood , Cell , Children , Diabetes , Diabetic Ketoacidosis , Endocrinology , Genetic , Glucose , Healthcare , Hyperglycemia , Insulin , Type 1 Diabetes
News > Healio news

Insulin degludec noninferior to insulin detemir for pregnant women with type 1 diabetes

04/17/2023 — Key Takeaways: Women with type 1 diabetes who used insulin degludec during pregnancy had similar HbA1c and glucose profile as those who used insulin detemir. Safety
Scientific studies > PubMed Abstracts

Examining the Acute Glycemic Effects of Different Types of Structured Exercise Sessions in Type 1 Diabetes in a Real-World Setting: The Type 1 Diabetes and Exercise Initiative (T1DEXI).

04/02/2023 — glycemic control during and after exercise remains a major challenge for individuals with type 1 diabetes. Glycemic responses to exercise may differ by exercise type
News > News-Medical.net - News

Insulin resistance increases retinopathy and nephropathy risk in young type 1 diabetics

03/22/2023 — nephropathy, neuropathy, and retinopathy) in young adults with type 1 diabetes. Study design The study analyzed the data obtained from the Swedish pediatric registry for
Scientific studies > DOAJ

Efficacy of combination therapy with GABA, a DPP-4i and a PPI as an adjunct to insulin therapy in patients with type 1 diabetes

05/25/2023 — chart records, including, glucose >20 mmol/L, ketoacidosis, other clinical features (such as polydipsia and polyuria) at the onset, and records of insulin dependence on
Clinical trials > Clinical Trials - New studies

Automated Insulin Delivery in Type 1 Diabetes Complicated by Gastroparesis

04/03/2023 — Mellitus Diabetes Mellitus, Type 1 Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Autoimmune Diseases Immune System Diseases
News > News-Medical.net - News

Promising alternative strategy for islet transplantation in people with type 1 diabetes

03/01/2023 — levels and restored glucose-responsive insulin secretion in three nonhuman primates with type 1 diabetes for as long as the animals were tested. "The achievement of
News > TechSpot news

Fuel cell implant uses blood sugar to manage type 1 diabetes

03/30/2023 — cause of type 1 diabetes, in which the body doesn't naturally produce insulin, leading to dangerously high blood sugar levels. A group of researchers has unveiled a pair
News > Healio news

Advanced hybrid closed-loop therapy reduces HbA1c for adolescents with type 1 diabetes

03/28/2023 — Key takeaways: Teens and young adults with type 1 diabetes who switched to hybrid closed-loop insulin delivery reduced their HbA1c by 2.9 percentage points at 3 months
Scientific studies > PubMed Abstracts

Type 1 diabetes: Key drug targets and how they could influence future therapeutics.

02/07/2023 — therapy. These new therapeutic targets offer the hope of reducing the daily burden of diabetes management with eventual insulin discontinuation for many individuals with
Scientific studies > PubMed Abstracts

Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms.

04/14/2023 — causes of hypoglycemia were deemed possible to interpret and later validate by insulin and carbohydrate recordings: (1) overestimated bolus (27%), (2) overcorrection of
Scientific studies > PubMed Abstracts

Teplizumab Therapy to Delay the Onset of Type 1 Diabetes.

05/11/2023 — Display options Format AbstractPubMedPMID Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease that results in the destruction of insulin-producing pancreatic
Scientific studies > PubMed Abstracts

Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination.

01/10/2023 — type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year-old female patient who developed hyperglycemia after
Scientific studies > PubMed Abstracts

Challenges with Cell-based Therapies for Type 1 Diabetes Mellitus.

11/26/2022 — -mediated loss of insulin-producing pancreatic β cells in the islets of Langerhans (β-islets), resulting in disrupted glucose homeostasis. Administration of exogenous
Scientific studies > PubMed Articles

Skeletal manifestations in a streptozotocin-induced C57BL/6 model of Type 1 diabetes.

12/02/2022 — ensure persistent hyperglycemia and mice were euthanized at 15 weeks of age. Diabetes was confirmed through blood glucose monitoring, glucose and insulin tolerance testing
Press releases > McGill University - Press releases

Type 1 diabetes triggered by "lazy" regulatory T-cells: McGill researchers

01/12/2023 — beta islet cells in the pancreas are attacked and destroyed by the body’s own immune system. Patients must inject insulin on a regular basis or risk diabetic shock and death
News > Express & Star - UK news

Short activity bouts ‘can help type 1 diabetes patients with blood sugar levels’

04/23/2023 — attacks the insulin-producing cells of the pancreas, leading to high blood sugar levels. For the study, the participants completed two seven-hour sitting sessions – in one
Scientific studies > MDPI

Sensitivity to Sweet and Salty Tastes in Children and Adolescents with Type 1 Diabetes

12/30/2022 — implications for the intake of a particular type of food and for the development of eating habits and preferences. 1. Introduction Type 1 diabetes (T1D) is an autoimmune systemic
Press releases > Healio - News

CGM metrics comparable in type 1 diabetes with insulin glargine, insulin degludec

03/09/2023 — insulin degludec during both daytime and nighttime hours. CGM-derived hypoglycemia rates with a glucose level of less than 70 mg/dL were 2.9 times higher than self-measured
News > The Telegraph - UK news

Type 1 diabetes patients should walk every half-hour after sitting, research finds

04/24/2023 — condition occurs when the body’s immune system attacks the insulin-producing cells of the pancreas, leading to high blood-sugar levels. For the study, the participants
News > The Indian Express

How new drug delays onset of insulin shot stage in Type 1 diabetes

11/23/2022 — years. Unlike the more common Type 2 diabetes, where the body’s cells stop responding to the insulin produced by the pancreas, Type 1 diabetes patients stop producing insulin
Scientific studies > PubMed Articles

The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes.

02/02/2023 — . Keywords: Adult onset; Diabetes classification; Islet autoantibodies; Type 1 diabetes; Type 2 diabetes. © 2022. The Author(s). Figures Fig. 1 T1DGRS by islet autoantibody
Press releases > National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Diseases - Press Releases

Bionic pancreas improves type 1 diabetes management compared to standard insulin delivery methods NIH external link

11/22/2022 — ) . Automated insulin delivery systems, also called artificial pancreas or closed-loop control systems, track a person’s blood glucose levels using a continuous glucose monitor and
Scientific studies > MDPI

Therapeutic Nursing Education in Promoting Self-Management of Adolescents with Type 1 Diabetes Mellitus: Integrative Literature Review

03/16/2023 — through hyperglycemia that is evidenced by the following signs and symptoms: polydipsia, polyphagia, polyuria, glycosuria, sudden weight loss (despite polyphagia), tiredness
Scientific studies > DOAJ

Complete remission in children and adolescents with type 1 diabetes mellitus—prevalence and factors

05/01/2023 — al. A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults. Diabetes Care 39 , 337–344. https://doi.org/10.2337
Scientific studies > DOAJ

Circulating miRNA expression in long-standing type 1 diabetes mellitus

05/29/2023 — glucose homeostasis and lifelong insulin treatment need 1 . The most widely accepted theory attributes the development of type 1 diabetes to a combination of environmental
Scientific studies > PubMed Abstracts

Early Optical Coherence Tomography Angiography Changes among Children and Adolescents with Type 1 Diabetes; Relation to Fibroblast Growth Factor 21.

12/10/2022 — assessed for diabetes-duration, insulin therapy, hypoglycemia and diabetic-ketoacidosis frequency, Tanner staging, glycated-hemoglobin (HbA1c), fasting lipids, urinary albumin
Scientific studies > PubMed Articles

Gender gaps in type 1 diabetes care.

03/02/2023 — according to… Fig. 1 Cardiovascular risk score according to sex in adults with type 1 diabetes mellitus Fig. 1 Cardiovascular risk score according to sex in adults with type 1
Scientific studies > PubMed Articles

Chronic limb threatening disease, diabetic nephropathy and diabetic retinopathy in patients with type 1 diabetes.

05/02/2023 — Assoc Physicians India. 2022. PMID: 35443361 Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis. He
Scientific studies > PubMed Abstracts

Diabetes Therapy Podcast: Real-World Data for Glucose Sensing Technologies in Type 1 Diabetes.

11/26/2022 — , Polonsky W, Hirsch IB, et al. Continuous glucose monitoring vs conventional therapy for glycemic control in adults with type 1 diabetes treated with multiple daily insulin
Scientific studies > PubMed Abstracts

[A monogenetic disorder instead of type 1 diabetes].

04/20/2023 — during puberty. Case description: In this article we describe a woman who had been treated with insulin since early adulthood because of suspected type 1 diabetes (T1D
Scientific studies > PubMed Abstracts

Gut microbiome in type 1 diabetes: the immunological perspective.

11/20/2022 — Abstract Introduction: Type 1 diabetes (T1D) is a prevalent, and yet uncurable, autoimmune disease targeting insulin-producing pancreatic β-cells. Despite a known
Scientific studies > PubMed Abstracts

Glycemia Risk Index Assessment in a Pediatric and Adult Patient Cohort With Type 1 Diabetes Mellitus.

02/17/2023 — ; glycemia risk index; time in range; type 1 diabetes. Similar articles Continuous Subcutaneous Insulin Infusion (CSII) Pumps for Type 1 and Type 2 Adult Diabetic Populations
Scientific studies > DOAJ

How to end up on the podium after running a 6-days-run with type 1 diabetes mellitus – A case study and literature review

05/12/2023 — no hypoglycemia during the competition. The very rare blood sugar imbalances would also be more typical of type 2 diabetes mellitus. The runner can assess blood sugar
Scientific studies > PubMed Abstracts

Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.

03/17/2023 — insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually are unclear
Scientific studies > PubMed Abstracts

A perspective on treating type 1 diabetes mellitus before insulin is needed.

03/14/2023 — perspective on treating type 1 diabetes mellitus before insulin is needed Danijela Tatovic  1 , Parth Narendran  2 , Colin M Dayan  3 Affiliations Expand Affiliations 1
News > Medical Device Network - News

Medical technology for type 1 diabetes: how patients are taking charge of their lives

03/22/2023 — Photo credit: Andrey_Popov at Shutterstock Type 1 diabetes is a condition where the pancreas doesn’t make insulin. Without insulin, glucose stays in the blood because it
Scientific studies > MDPI

The Association between SARS-CoV-2 Infection and Diabetic Ketoacidosis in Patients with New-Onset Diabetes: A Retrospective Study from a Diabetic Center in Saudi Arabia

11/29/2022 — .; Jansson, L. Angiotensin II and the Endocrine Pancreas: Effects on Islet Blood Flow and Insulin Secretion in Rats. Diabetologia 1998 , 41, 127–133. [ Google Scholar
Scientific studies > DOAJ

The prevalence of diabetic peripheral neuropathy in youth with diabetes mellitus

04/05/2023 — complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86. 23. Trotta D, Verrotti A, Salladini C, Chiarelli F. Diabetic neuropathy in children and
Scientific studies > PubMed Articles

Hypoglycemia Detection Using Hand Tremors: Home Study of Patients With Type 1 Diabetes.

04/20/2023 — hypoglycemic events. Keywords: acceleration; accelerometer; algorithm; blood sugar; detect; diabetes; diabetic; digital measurement; frequency domain; glucose; hand
Scientific studies > PubMed Abstracts

Regression from stage 3 to stage 2 type 1 diabetes mellitus after discontinuing growth hormone therapy.

05/17/2023 — insulin levels for the degree of hyperglycemia as well as seropositivity of zinc transporter antibody and islet antigen-2 antibody. Additional laboratory data obtained 2
Scientific studies > PubMed Abstracts

Time-Action Profile of Technosphere Insulin in Children with Type 1 Diabetes.

01/19/2023 — technosphere insulin demonstrates reduction in postprandial glucose excursions and hemoglobin A1c in patients with type 2 diabetes. Tack CJ, Christov V, de Galan BE, Derwahl KM
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