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News > BioPharm International - News

The COVID-19 Pandemic and Its Positive Impact on RNA Drug Development

02/01/2023 — acids by Watson and Crick and later studies on messenger RNA (mRNA) molecule in the 1960s. However, it took decades for RNA biology to “explode” in the 1990s and early 2000s
Scientific studies > MDPI

The Repertoire of RNA Modifications Orchestrates a Plethora of Cellular Responses

01/25/2023 — , C.L. Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo. Nat. Commun. 2019 , 10, 3401. [ Google Scholar ] [ CrossRef ] Dai, Q.; Moshitch
Patent filings > APPFT - Patent Applications

NOVEL MRNA COMPOSITION AND PRODUCTION METHOD FOR USE IN ANTI-VIRAL AND ANTI-CANCER VACCINES

12/15/2022 — may encode a protein-coding RNA essential for protein/peptide synthesis, such as messenger RNA (mRNA) and its RNA precursors as well as derivatives. In some cases, a gene
Scientific studies > MDPI

Matrices Activated with Messenger RNA

01/15/2023 — confirmed that gene therapy-activated matrices are potent tools for sustained gene modulation at the implantation area. Matrices activated with messenger RNA (mRNA) are
Press releases > PR Newswire - All News Releases

Global Messenger RNA (mRNA) Vaccines & Therapeutics Markets, 2022-2023 & 2028: Rising Demand for Therapeutic Drugs and Vaccines for Ebola, influenza, HIV, and Other Viral Illnesses

01/07/2023 — DUBLIN, Jan. 6, 2023 /PRNewswire/ -- The "Messenger RNA (mRNA) Vaccines & Therapeutics Market, Size, Global Forecast 2023-2028, Industry Trends, Growth, Impact of
Patent filings > APPFT - Patent Grants

Optimization of gene sequences for protein expression

12/27/2022 — . The ribosome decodes each 3-nt codon in the messenger RNA (mRNA) and adds each specified amino acid to the new protein chain. Ribosome profiling can measure translation by
Patent filings > APPFT - Patent Applications

Dry Powder Formulations for Messenger RNA

01/05/2023 — expressed intracellularly or with limited secretion that avoids entering the patient's circulation system.r />[0080] Messenger RNA (mRNA): As used herein, the term
News > The Economic Times - India

Countries which chose Covishield fared better than those that took mRNA vax: Adar Poonawalla

01/29/2023 — messenger RNA vaccines aren't as good as the traditional vaccine, which is why I never went down the messenger RNA route for Covid. We can see that in real world data
News > ACCESSWIRE - News

Moderna to Report Fourth Quarter and Full Year 2022 Financial Results on Thursday, February 23, 2023

02/02/2023 — CAMBRIDGE, MA / ACCESSWIRE / February 2, 2023 / Moderna, Inc. (NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today
Scientific studies > PubMed Articles

Effectiveness of Messenger RNA-1273 Vaccine Booster Against Coronavirus Disease 2019 in Immunocompetent Adults.

01/14/2023 — study at Kaiser Permanente Southern California to evaluate the relative vaccine effectiveness (rVE) of a booster dose vs 2-dose primary series of messenger RNA (mRNA
News > News-Medical.net - News

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

01/29/2023 — women from initial COVID-19 messenger RNA (mRNA) vaccine trials. Nevertheless, a robust maternal immune response has been reported after vaccination with mRNA-lipid
Scientific studies > PubMed Abstracts

Subclinical myocardial assessment after BNT162b2 messenger RNA COVID-19 vaccination in adolescents with chronic heart disease: a speckle-tracking echocardiography study.

01/19/2023 — development of perimyocarditis in adolescents and young adults after BNT162b2 messenger RNA (mRNA) COVID-19 vaccination have raised concerns about the cardiac side
Patent filings > APPFT - Patent Applications

Methods for Purification of Messenger RNA

12/29/2022 — abstractHtml The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising in
Patent filings > APPFT - Patent Applications

METHODS FOR PURIFICATION OF MESSENGER RNA

12/22/2022 — '] curIntlPatentClassificationSecondaryDateKwicHits None abstractHtml The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from
Scientific studies > PubMed Abstracts

The role of GTP hydrolysis by EF-G in ribosomal translocation.

10/26/2022 — .2212502119 Item in Clipboard CiteDisplay options Display options Format AbstractPubMedPMID Abstract Translocation of transfer RNA (tRNA) and messenger RNA (mRNA
Scientific studies > PubMed Abstracts

Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.

02/01/2023 — Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA Hiroki Tanaka  1 , Shinya Hagiwara  1 , Daiki Shirane  1 , Takuma Yamakawa  1 , Yuka
Scientific studies > PubMed Articles

Association of interstitial granulomatous dermatitis with messenger Rna-1273 Sars-Cov-2 vaccine.

01/02/2023 — Images of Interstitial granulomatous drug‐induced dermatitis‐associated with messenger RNA (mRNA)–1273 SARS‐CoV‐2 Vaccine.… FIGURE 1 Clinical Images of Interstitial
Scientific studies > PubMed Abstracts

Modelling ribosome kinetics and translational control on dynamic mRNA.

01/24/2023 — translational level, where interactions of proteins and ribosomes with the messenger RNA determine protein translational efficiency. Although transcriptional control of mRNA levels
Scientific studies > PubMed Articles

MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer.

02/02/2023 — their complementary target messenger RNA (mRNA). MiRNAs modulate fundamental biological processes and play crucial roles in the pathology of various diseases, including PCa
Regulatory filings > Food and Drug Administration - New Vaccines, Blood and Biologics

Synonymous mutation increases in vitro production and activity of enzyme that reduces blood clotting

10/25/2022 — are groups of three nucleotide building blocks of DNA or its decoded form, messenger RNA (mRNA). Each codon encodes a specific amino acid building block of a particular
Scientific studies > PubMed Abstracts

New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease.

11/24/2022 — (a) [apo(a)] component of Lp(a), supporting the use of nucleic acids that inhibit the messenger RNA (mRNA) gene transcript for apo(a). Analytical barriers to measurement
Scientific studies > PubMed Abstracts

RNAdegformer: accurate prediction of mRNA degradation at nucleotide resolution with deep learning.

01/13/2023 — Format AbstractPubMedPMID Abstract Messenger RNA-based therapeutics have shown tremendous potential, as demonstrated by the rapid development of messenger RNA based
Scientific studies > PubMed Articles

T-Cell Mediated Response after Primary and Booster SARS-CoV-2 Messenger RNA Vaccination in Nursing Home Residents.

02/02/2023 — -Cell Mediated Response after Primary and Booster SARS-CoV-2 Messenger RNA Vaccination in Nursing Home Residents Ilaria Schiavoni  1 , Annapina Palmieri  2 , Eleonora
Scientific studies > PubMed Abstracts

Cryo-EM structure of the fully assembled Elongator complex.

01/10/2023 — Format AbstractPubMedPMID Abstract Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified
News > Genetic Engineering & Biotechnology News (GEN) - News

Advancing mRNA Therapeutics with Engineered Enzymes

01/30/2023 — Genetic Engineering & Biotechnology News Broadcast Date: March 28, 2023 Messenger RNA (mRNA) therapies have gained tremendous traction with the approval of mRNA vaccines
Press releases > Businesswire - Health News

CF Foundation Invests Up to $15M in ReCode Therapeutics for Development of mRNA Therapy

01/10/2023 — BETHESDA, Md.--( BUSINESS WIRE )--The Cystic Fibrosis Foundation will invest up to $15 million in ReCode Therapeutics for the development of its messenger RNA (mRNA
Press releases > McGill University - Press releases

McGill researchers find key to messenger RNA control

01/12/2023 — microRNAs to control messenger RNA, one of the major gene regulators in life, outside the confines of a living cell for the first time. In research led by McGill
News > The Economic Times - India

Cipla invests in Ethris for mRNA-based inhalation therapies

12/29/2022 — The investment will facilitate a long-term strategic partnership between Cipla and Ethris for the development of messenger RNA (mRNA)-based therapies and fast-track
Patent filings > APPFT - Patent Grants

Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

01/03/2023 — messenger RNA (mRNA), the aa-tRNA binds to the ribosome and its amino acid is incorporated into the nascent protein chain. Since all tRNAs that base-pair with a specific codon
Patent filings > APPFT - Patent Applications

TREATMENTS FOR CHARCOT-MARIE-TOOTH DISEASE

12/08/2022 — inhibitor”) is administered to a subject. A GCN2 pathway component is an any polynucleotide (e.g., DNA or RNA, e.g., a gene or gene transcript) or polypeptide (e.g
News > BioPharm International - News

The Commercial Message mRNA Products Send

02/01/2023 — Messenger RNA (mRNA)-based vaccines have been largely optimized for stability, structure, and delivery. Integration of naturally occurring modified nucleosides, such as
News > Fox News

Moderna says its RNA vaccine was nearly 84% effective in preventing symptoms in adults 60 and older

01/18/2023 — Moderna Inc. announced on Tuesday that a late-stage trial found that its experimental messenger RNA vaccine for respiratory syncytial virus was 83.7% effective in
News > The Medical News

Using lipid nanoparticles and messenger RNA to treat blindness associated with rare genetic condition

01/12/2023 — Oregon State University College of Pharmacy scientists have demonstrated in animal models the possibility of using lipid nanoparticles and messenger RNA, the technology
News > Pharmtech Focus - News

Personalis and Moderna Sign New Agreement to Leverage NeXT Platform™ in Personalized mRNA Cancer Vaccine Clinical Trials

02/03/2023 — Personalis , a leader in advanced genomics for precision oncology, and Moderna , a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines
News > ScienceDaily - News

Researchers take key step toward new treatment for hereditary blindness

01/13/2023 — Oregon State University College of Pharmacy scientists have demonstrated in animal models the possibility of using lipid nanoparticles and messenger RNA, the technology
Scientific studies > PubMed Abstracts

Highly efficient mRNA delivery with nonlinear microfluidic cell stretching for cellular engineering.

02/03/2023 — /d2lc01115h Item in Clipboard CiteDisplay options Display options Format AbstractPubMedPMID Abstract In the past few years, messenger RNA (mRNA) has emerged as a
Press releases > PR Newswire - All News Releases

Cipla EU to Invest EUR 15 million in Ethris, initiating a strategic collaboration

12/29/2022 — investment will facilitate a long-term strategic partnership between Cipla and Ethris for the development of messenger RNA (mRNA)-based therapies and fast-track Cipla's
Scientific studies > PubMed Abstracts

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans.

02/03/2023 — identify messenger RNA (mRNA) rhythms in 46 tissues. Clock transcripts showed conserved timing relationships and tight synchrony across the body. mRNA rhythms varied in breadth
Scientific studies > PubMed Articles

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

02/02/2023 — oxidase-like protein 2; mRNA, messenger RNA; PDAC, pancreatic ductal adenocarcinoma; TCGA, The Cancer Genome Atlas. Figure 2 Macrophages induce LOXL2 and EMT… Figure 2
Scientific studies > PubMed Abstracts

Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial.

12/20/2022 — to either homologous (BNT162b2 + BNT162b2 + BNT162b2; "BBB") or heterologous messenger RNA (mRNA) (BNT162b2 + BNT162b2 + mRNA-1273; "BBM") booster vaccine. The primary
Scientific studies > PubMed Abstracts

Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer.

01/28/2023 — Display options Format AbstractPubMedPMID Abstract Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs remains challenging. To
News > The Indian Express

Covid-19: Amid growing concerns about their adverse effects, your basic guide to understanding mRNA vaccines

01/10/2023 — peer-reviewed research that re-analysed Pfizer and Moderna trials for mRNA Covid-19 vaccine , has claimed that the messenger RNA (mRNA) vaccine can increase serious adverse
Scientific studies > PubMed Abstracts

Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia.

12/23/2022 — , myelodysplastic syndrome or chronic myelomonocytic leukaemia were examined for protein (fluorescence-activated cell sorting) and messenger RNA (mRNA) expression (quantitative
News > Medical Xpress

Bivalent COVID vaccines have now been in use for a few months—here's how they're stacking up against omicron

01/11/2023 — genetic material known as messenger RNA that give instructions to our cells to make copies of the coronavirus spike protein. Once these spike proteins are made, they're
News > BioPharm International - News

AbbVie and Anima Biotech Partner on Discovery and Development of mRNA Biology Modulators

01/18/2023 — AbbVie and US-based Anima Biotech (Anima) have formed a collaboration to discover and develop messenger RNA (mRNA) biology modulators for three targets across oncology
Scientific studies > PubMed Abstracts

The effect of microRNA on protein variability and gene expression fidelity.

01/26/2023 — AbstractPubMedPMID Abstract Small regulatory RNA molecules such as microRNA modulate gene expression through inhibiting the translation of messenger RNA (mRNA). Such post
Scientific studies > MDPI

The Origin of Translation: Bridging the Nucleotides and Peptides

12/22/2022 — settings compared to RNA-coded peptide formation. Nowadays, translation takes place in the endoplasmic reticulum membrane in the cytoplasm with messenger RNA as the
Patent filings > APPFT - Patent Applications

mRNA VACCINE AND METHOD OF INDUCING ANTIGEN-SPECIFIC IMMUNE RESPONSES IN INDIVIDUALS

12/15/2022 — gene of interest and a ligand sequence encoding a CD40 ligand. In some embodiments, the present invention further provides a method of delivering a messenger RNA
Press releases > Businesswire - Health News

Arcturus Therapeutics to Present at the 41st Annual J.P. Morgan Healthcare Conference

12/19/2022 — SAN DIEGO--( BUSINESS WIRE )--Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a global late-stage clinical messenger RNA medicines company
News > Business Recorder - Pakistan

Davos 2023: Moderna CEO in talks with China to supply COVID vaccines

01/18/2023 — hometowns this week for the Lunar New Year holidays. China-made COVID vaccines are of the inactivated virus type and not based on the messenger RNA technology used in the
Press releases > Healio - News

Intrarenal podocalyxin level may predict dialysis-free survival in diabetic kidney disease

01/24/2023 — quantitative polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA). Although the urinary podocalyxin level was associated with its messenger RNA level
News > Lab Manager - News

New Research Promises Potential Treatment for Hereditary Blindness

01/16/2023 — nanoparticles (LNPs) and messenger RNA, the same technique upon which mRNA COVID-19 vaccines are built. In a study published in Science Advances , the authors describe the
Press releases > Businesswire - Science News

Ethris Announces Collaboration with DIOSynVax and CEPI to Develop a Broadly Protective mRNA Vaccine Against Betacoronaviruses

12/21/2022 — Innovations (CEPI) MUNICH--( BUSINESS WIRE )-- Ethris GmbH , a leading biotechnology company pioneering next-generation messenger RNA (mRNA) therapeutics and vaccines, announced
Scientific studies > PubMed Abstracts

Differentially expressed messenger RNA/proteins can distinguish teratoma from necrosis in postchemotherapy retroperitoneal lymph node dissection (pcRPLND) tissue.

12/12/2022 — viable GCT. The purpose of this study was to explore messenger RNA (mRNA) and proteins to distinguish TER from NEC in pcRPLND tissue. Methods: The discovery cohort
Press releases > Businesswire - Health News

Recode Therapeutics Expands Leadership Team with Appointment of April Loui as Senior Vice President of Quality and CMC Regulatory Affairs

02/01/2023 — Therapeutics ReCode Therapeutics is a genetic medicines company using superior delivery to power the next wave of messenger RNA (mRNA) and gene correction therapeutics. ReCode’s
Scientific studies > MDPI

The microRNA Lifecycle in Health and Cancer

11/23/2022 — ) regulate messenger RNA (mRNA) expression at the post-transcriptional level. They play an important role within physiological and pathological cellular processes by
Scientific studies > PubMed Abstracts

Messenger RNA in lipid nanoparticles rescues HEK 293 cells from lipid-induced mitochondrial dysfunction as studied by real time pulse chase NMR, RTPC-NMR, spectroscopy.

12/25/2022 — Sci Rep Actions Search in PubMed Search in NLM Catalog Add to Search . 2022 Dec 24;12(1):22293. doi: 10.1038/s41598-022-26444-z. Messenger RNA in lipid nanoparticles
Scientific studies > PubMed Abstracts

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts.

12/19/2022 — mRNA delivery systems targeting fibrotic diseases. Keywords: CRISPR/Cas9; gene edition; high-throughput screening; messenger RNA; polymeric nanoparticles. © 2022 The
Scientific studies > PubMed Abstracts

A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway.

01/14/2023 — /sciadv.ade2828 Item in Clipboard CiteCollectionsDisplay options Display options Format AbstractPubMedPMID Abstract Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been
Scientific studies > PubMed Articles

Off-label prescription of BNT162b2 mRNA COVID-19 vaccine to <5-year-old children in the European Union.

02/02/2023 — . Dal‐Ré has no interest to declare. Similar articles Comparative Safety of the BNT162b2 Messenger RNA COVID-19 Vaccine vs Other Approved Vaccines in Children Younger
Scientific studies > PubMed Articles

The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice.

02/02/2023 — , glyceraldehyde-3-phosphate dehydrogenase; GSDMD, gasdermin D; IL, interleukin; IOD, integral optical density; IRI, ischemia-reperfusion injury; mRNA, messenger RNA; MyD88
News > The Medical News

Research uncovers a new way to boost the effectiveness of RNA therapies

12/20/2022 — naturally stabilize the heartbeat." In the latest research study, Cingolani and team harnessed the same modified messenger RNA (mRNA) technology used in creating the Pfizer and
Scientific studies > PubMed Articles

Persistent pruritus following COVID-19 vaccination.

02/02/2023 — messenger RNA COVID-19 vaccination: A case report and review of the literature. Buckley JE, Landis LN, Rapini RP. Buckley JE, et al. JAAD Int. 2022 Jun;7:164-168. doi: 10.1016
Scientific studies > PubMed Articles

Imaging characteristics of myocarditis after mRNA-based COVID-19 vaccination: a meta-analysis.

02/02/2023 — Free PMC article. Review. See all similar articles References Wang M, Wen W, Zhou M, Wang C, Feng ZH. Meta‐analysis of risk of myocarditis after messenger RNA COVID‐19
News > GenomeWeb - News

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

11/28/2022 — messenger RNA (mRNA) degradation rates in humans and mice. Using transcriptome-wide mRNA half-life patterns found in dozens of human or mouse datasets, the team used available
Press releases > Healio - News

CDC publishes first estimates of bivalent boosters’ effectiveness against XBB.1.5

01/25/2023 — MMWR, CDC researchers reported that vaccination with a bivalent messenger RNA booster had a relative vaccine effectiveness of 49%, 40% and 43% against symptomatic
Scientific studies > MDPI

Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery

02/01/2023 — Open AccessCommunication Abstract Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the
News > Toronto Sun - Canada

Experimental skin cancer vaccine shows promising early results

12/13/2022 — cancer vaccine using messenger RNA may be effective, two pharmaceutical companies announced Tuesday. An experimental cancer vaccine, combined with another drug, performed
News > Manila Bulletin - Philippines

Moderna, Merck see positive results from skin cancer vaccine

12/14/2022 — WASHINGTON, United States – The Moderna and Merck drug makers on Tuesday announced positive results from a trial in which messenger RNA technology was used for the first
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