News > Genetic Engineering & Biotechnology News (GEN) news

Ribosome Decoding Methods Used by Humans and Bacteria Open Door to Novel Drug Discovery Opportunities

04/07/2023 — messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems
Scientific studies > PubMed Abstracts

Decoding and Recoding of mRNA Sequences by the Ribosome.

05/10/2023 — the links among mRNA signals, ribosome dynamics, and recoding. Keywords: EF-G; EF-Tu; frameshifting; kinetics; ribosome; stop codon readthrough; tRNA; translation. Publication types Review Actions Search in PubMed Search in MeSH Add to Search
Scientific studies > DOAJ

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

04/25/2023 — transporter RNA (tRNA), messenger RNA (mRNA), and long non-coding RNA (lncRNA) ( Trixl and Lusser, 2019 ). m5C modifications on RNA are widespread and play an important role in
Scientific studies > PubMed Articles

Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases.

03/15/2023 — considered as messenger RNA (mRNA) 5' caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal
Scientific studies > PubMed Abstracts

The role of GTP hydrolysis by EF-G in ribosomal translocation.

10/26/2022 — .2212502119 Item in Clipboard CiteDisplay options Display options Format AbstractPubMedPMID Abstract Translocation of transfer RNA (tRNA) and messenger RNA (mRNA
Blogs and journals > A-Z-Animals blog

Where Does Transcription and Translation Occur? Tips to Remember the Difference

05/17/2023 — 3’ end of the molecule. Finally, introns (sequences in the gene that are not expressed in the RNA product) are spliced from the pre-mRNA so only exons remain (parts of
Patent filings > APPFT - Patent Applications


12/15/2022 — from a gene without any RNA processing or modification.r />[0026] Precursor messenger RNA (pre-mRNA): primary RNA transcripts of a protein-coding gene, which are produced
News > BioPharm International - News

The COVID-19 Pandemic and Its Positive Impact on RNA Drug Development

02/01/2023 — acids by Watson and Crick and later studies on messenger RNA (mRNA) molecule in the 1960s. However, it took decades for RNA biology to “explode” in the 1990s and early 2000s
Scientific studies > MDPI

The Repertoire of RNA Modifications Orchestrates a Plethora of Cellular Responses

01/25/2023 — . Adenine to Inosine (A-to-I) In humans, the most common RNA editing procedure that results in the substitution of a specific nucleotide is adenine-to-inosine (A-to-I); in mRNA
Scientific studies > DOAJ

RNA methylation in plants: An overview

03/01/2023 — ( Mongan et al., 2019 ). 2’-O-Methylation coupled with MeRIP-Seq comprehensively detect 2’-O-RNA methylation at single-base resolution in different RNAs such as tRNA, mRNA
News > PharmTech news

Ramping Up Nucleic Acid Therapy Development

05/03/2023 — mainstream. “On the other end of these therapies sits mRNA, which tells the body to produce, or turn on, specific proteins that the mRNA encodes for. [Messenger] RNA is like a
News > BioPharm International news

Ramping Up Development of Nucleic Acid Therapies

04/03/2023 — acid-based therapies include RNA interference (RNAi), antisense oligonucleotides (ASOs), and the now-familiar messenger RNA (mRNA) therapeutics. RNAi therapeutics utilize a
Scientific studies > PubMed Abstracts

CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex.

02/15/2023 — ' mRNA I-shaped structure of maize necrotic streak virus binds to eukaryotic translation factors for eIF4F-mediated translation initiation. Liu Q, Goss DJ. Liu Q, et al. J
Scientific studies > PubMed Articles

Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer's disease and traumatic brain injury.

04/02/2023 — scores and in individuals with a history of traumatic brain injury (TBI). We found an increase in the DNA methylation writers DNMT1, DNMT3A and DNMT3B messenger RNA (mRNA) and
Scientific studies > DOAJ

Epitranscriptomics in the development, functions, and disorders of cancer stem cells

03/18/2023 — stability and biogenesis of tRNA ( 76 ) In contrast, NSUN2 has a wider range of target specificity, including long noncoding RNA (lncRNA), mRNA, and other small regulatory
Scientific studies > PubMed Articles

YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522.

04/02/2023 — analysis for tRF-GlyTCC, YBX1 and RUNX2. F. Using stored RNA from sequencing experiments and RNA isolated from micromass experiments, ectopic tRF-GlyTCC reduced RUNX2 mRNA and
Press releases > Businesswire - Health News

Global Messenger RNA (mRNA) Vaccines & Therapeutics Markets, 2022-2023 & 2028: COVID-19 Impacts, Industry Trends, Growth, Impact of Inflation, Opportunity Company Analysis - ResearchAndMarkets.com

01/05/2023 — $ 11.63 Billion in 2022 and is expected to reach US$ 26.34 Billion by 2028 Messenger Ribonucleic Acid (mRNA) is a term that refers to a single protein-coding gene in the
Press releases > PR Newswire - All News Releases

Global Messenger RNA (mRNA) Vaccines & Therapeutics Markets, 2022-2023 & 2028: Rising Demand for Therapeutic Drugs and Vaccines for Ebola, influenza, HIV, and Other Viral Illnesses

01/07/2023 — RNA (mRNA) Vaccines & Therapeutics Market 8.1 Cancer 8.2 Infectious Diseases 8.3 Others 9. End User - Global Messenger RNA (mRNA) Vaccines & Therapeutics Market 9.1
Scientific studies > MDPI

Matrices Activated with Messenger RNA

01/15/2023 — confirmed that gene therapy-activated matrices are potent tools for sustained gene modulation at the implantation area. Matrices activated with messenger RNA (mRNA) are
Press releases > PR Newswire - All News Releases

USD 26.35 Billion Growth in mRNA Vaccines & Therapeutics Market Size - Industry Analysis, Market Trends, Market Growth, Opportunities

05/03/2023 — with All Related Graphs & Charts : https://www.fnfresearch.com/mrna-vaccines-and-therapeutics-market Messenger RNA (mRNA) Vaccines & Therapeutics Market: Overview Messenger
News > Toronto Star - Canada

NOT REAL NEWS: A look at what didn’t happen this week

10/07/2022 — helix. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. The mRNA in the COVID-19 vaccines
Scientific studies > PubMed Abstracts

New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease.

11/24/2022 — (a) [apo(a)] component of Lp(a), supporting the use of nucleic acids that inhibit the messenger RNA (mRNA) gene transcript for apo(a). Analytical barriers to measurement
Patent filings > APPFT - Patent Grants

Optimization of gene sequences for protein expression

12/27/2022 — -protected mRNA fragments, and comprises contacting the RNA molecules with an enzymatic degradant or a chemical degradant thereby forming RNA fragments, wherein each RNA
Patent filings > APPFT - Patent Applications


12/22/2022 — '] curIntlPatentClassificationSecondaryDateKwicHits None abstractHtml The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of (a) precipitating mRNA from
Patent filings > APPFT - Patent Applications

Methods for Purification of Messenger RNA

12/08/2022 — , water, etc.).r />[0041] messenger RNA (mRNA): As used herein, the term “messenger RNA (mRNA)” refers to a polynucleotide that encodes at least one polypeptide, mRNA as used
Patent filings > APPFT - Patent Applications

Dry Powder Formulations for Messenger RNA

01/05/2023 —messenger RNA (mRNA)” refers to a polynucleotide that encodes at least one polypeptide. mRNA as used herein encompasses both modified and unmodified RNA. mRNA may contain one or
Scientific studies > PubMed Abstracts

Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.

04/22/2023 — ; GSH: glutathione; MPH: mouse primary hepatocyte; mRNA: messenger RNA; NAPQI: N-acetyl-p-benzoquinone imine; ROS: reactive oxygen species; SEM: standard error of the mean
Scientific studies > PubMed Abstracts

m5U-SVM: identification of RNA 5-methyluridine modification sites based on multi-view features of physicochemical features and distributed representation.

04/25/2023 — , Bhattarai DP, Xiao W. 5-methylcytosine promotes mRNA export—NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res. 2017;27(5):606–25. - DOI
Scientific studies > DOAJ

The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications

04/10/2023 — methods of RNA modification discovered to date, m6A methylation is the most common and abundant epigenetic modification of RNA. m6A was first discovered in mRNA in the 1970s 2
Patent filings > APPFT - Patent Applications


09/16/2022 — " refers to a RNA transcript that is complementary to all or part of a target primary transcript or mRNA and that blocks the expression of a target gene (U.S. Pat. No. 5,107,065
Press releases > Arizona State University - Press Releases

ASU scientists discover dual-function messenger RNA

10/04/2022 — the Mechanism of Evolution — has discovered an unprecedented pathway producing telomerase RNA from a protein-coding messenger RNA (mRNA). The central dogma of molecular
Scientific studies > PubMed Abstracts

Effectiveness of Messenger RNA-1273 Vaccine Booster Against Coronavirus Disease 2019 in Immunocompetent Adults.

01/14/2023 — , coronavirus disease 2019; KPSC, Kaiser Permanente Southern California; mRNA, messenger RNA. Figure 2. Cumulative incidence estimates of SARS-CoV-2… Figure 2. Cumulative
News > BioPharm International - News

The Marriage of RNA and Mass Spectrometry

03/01/2023 — (3). Currently, RNA-based medicines can be segregated by their functionality and structure and include species, such as messenger RNA (mRNA), antisense oligonucleotides
Scientific studies > DOAJ

Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment

04/07/2023 — dysfunctional expression of miRNA to cancer. 3.2 Messenger RNA (mRNA) As opposed to long non-coding RNA (RNA molecules that are not translated into proteins), mRNAs are the
Press releases > Oregon State University - News

Nanotechnology, messenger RNA combined in possible new ‘universal’ COVID-19 treatment

10/18/2022 — researcher Jeonghwan Kim. “The synthesis of mRNA is fast, affordable and scalable, and LNP-delivered mRNA can be repeated as necessary to sustain protein production until the
Scientific studies > PubMed Articles

Association of interstitial granulomatous dermatitis with messenger Rna-1273 Sars-Cov-2 vaccine.

01/02/2023 — granulomatous drug‐induced dermatitis‐associated with messenger RNA (mRNA)–1273 SARS‐CoV‐2 Vaccine. (a) Erythematous to violaceous plaque with annular configuration associated
Patent filings > APPFT - Patent Applications


12/08/2022 — by binding messenger RNA (mRNA) molecules and inhibiting translation. Non-limiting examples of RNA interference molecules that may be used as provided herein include
News > The Economic Times - India

Countries which chose Covishield fared better than those that took mRNA vax: Adar Poonawalla

01/29/2023 — countries who relied only on m RNA. But then are you not using the mRNA platform for other vaccines as experts call it a new era in vaccinology? We are looking at mRNA
Scientific studies > MDPI

The microRNA Lifecycle in Health and Cancer

11/23/2022 — based on complementarity between miRNA and messenger RNA (mRNA), translation is repressed or the mRNA is degraded. Binding of the miRISC to the target mRNA can induces
Scientific studies > DOAJ

TRA2: The dominant power of alternative splicing in tumors

04/20/2023 — messenger RNA (pre-mRNA), which includes splicing exons and introns prior to developing into mature mRNA, which usually occurs at high fidelity to produce functional mRNA. RNA
News > SciTechDaily: Combustion news

MIT Pioneers Gene Editing mRNA Nanoparticles To Combat Lung Diseases

04/04/2023 — diseases of the liver are now underway. RNA-based Covid-19 vaccines, which are injected directly into muscle tissue, have also proven effective. In many of those cases, mRNA
Scientific studies > PubMed Abstracts

Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery.

05/02/2023 — for the delivery of messenger RNA (mRNA) is slow and expensive, partly due to the lack of predictive power of in vitro screening methods and the low-throughput nature of
News > GenomeWeb - News

Computational Tool Predicts Mammalian Messenger RNA Degradation Rates

11/28/2022 — messenger RNA (mRNA) degradation rates in humans and mice. Using transcriptome-wide mRNA half-life patterns found in dozens of human or mouse datasets, the team used available
Blogs and journals > The Naked Scientists feature articles

Synthetic Biology: Making Life from Scratch

04/21/2023 — part (the gene) unwinds itself and the two strands separate, ready to be transcribed into messenger RNA (mRNA). The mRNA then takes the coded message outside of the cell
News > GenomeWeb news

Messenger RNA Decay Patterns Compiled in Bacterial Atlas

05/24/2023 — (mRNA) degradation in relation to mRNA translation in species with or without 5'-3' exonucleases. With the help of a 5' monophosphorylated (5'P) sequencing strategy
Scientific studies > PubMed Abstracts

Subclinical myocardial assessment after BNT162b2 messenger RNA COVID-19 vaccination in adolescents with chronic heart disease: a speckle-tracking echocardiography study.

01/19/2023 — development of perimyocarditis in adolescents and young adults after BNT162b2 messenger RNA (mRNA) COVID-19 vaccination have raised concerns about the cardiac side
Scientific studies > PubMed Abstracts

Circulating cell-free messenger RNA secretome characterization of primary sclerosing cholangitis.

05/24/2023 — unclear, and therapeutic options are limited. Methods: We performed cell-free messenger RNA (cf-mRNA) sequencing to characterize the circulating transcriptome of PSC and
Scientific studies > PubMed Abstracts

The 5'-3' mRNA Decay Pathway Modulates the Plant Circadian Network in Arabidopsis.

11/23/2022 — RNA (mRNA) levels require the regulation of mRNA production and degradation. While transcription factors controlling clock function have been well characterized from
Scientific studies > PubMed Abstracts

Antibody Responses and Reactogenicity of a Heterologous, Full-Dose Messenger RNA-1273 Booster in Heavily SARS-CoV-2-Exposed CoronaVac-Vaccinated Health-Care Workers in Indonesia: A Real-World Observational Study.

12/01/2022 — options Format AbstractPubMedPMID Abstract Real-world data on heterologous boosting with messenger RNA (mRNA)-1273 (Moderna) after inactivated COVID-19 vaccination are
Scientific studies > DOAJ

Stress granules: potential therapeutic targets for infectious and inflammatory diseases

05/03/2023 — phosphorylation, which ultimately leads to inhibited mRNA translation, RNase L-mediated RNA degradation, etc. ( 44 ). In addition, viral nucleic acid molecules of RNA and DNA
News > The Economic Times - India

Cipla invests in Ethris for mRNA-based inhalation therapies

12/29/2022 — messenger RNA (mRNA)-based therapies and fast-track Cipla’s participation in the mRNA space, enabling it to provide access to cutting-edge solutions developed by Ethris
News > Legal Insurrection news

NIH Begins Enrolling Volunteers in Clinical Trial for mRNA-Based Universal Flu Vaccine

05/18/2023 — shot every year. Messenger RNA, or mRNA, is the technology behind Moderna’s and Pfizer ’s widely used Covid vaccines. NIH played a crucial role in developing the mRNA
Scientific studies > PubMed Abstracts

Polymer-based mRNA delivery strategies for advanced therapies.

02/14/2023 — CiteDisplay options Display options Format AbstractPubMedPMID Abstract Messenger RNA (mRNA) based therapies offer great promise for the treatment of a variety of
News > Scienmag - News

Funding to Daniel Anderson’s lab will advance research on new delivery technology for RNA vaccines and therapies

04/11/2023 — development of mRNA vaccines and therapeutics for a variety of diseases. Anderson’s research has led to the development of several RNA delivery formulations that are in
Scientific studies > PubMed Abstracts

Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial.

12/20/2022 — diagram. Abbreviations: BBB, BNT162b2- BNT162b2- BNT162b2; BBM, BNT162b2-BNT162b2-mRNA-1273; D28, day 28; mRNA, messenger RNA. Figure 2. Level of severe acute respiratory
Press releases > Accesswire news

Moderna to Report First Quarter 2023 Financial Results on Thursday, May 4, 2023

04/20/2023 — call. About Moderna In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA
News > ACCESSWIRE - News

Moderna to Report Fourth Quarter and Full Year 2022 Financial Results on Thursday, February 23, 2023

02/02/2023 — Moderna In 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a
Scientific studies > PubMed Abstracts

Differentially expressed messenger RNA/proteins can distinguish teratoma from necrosis in postchemotherapy retroperitoneal lymph node dissection (pcRPLND) tissue.

12/12/2022 — viable GCT. The purpose of this study was to explore messenger RNA (mRNA) and proteins to distinguish TER from NEC in pcRPLND tissue. Methods: The discovery cohort
Scientific studies > PubMed Abstracts

RNAdegformer: accurate prediction of mRNA degradation at nucleotide resolution with deep learning.

01/13/2023 — -making. Further, our model reveals important features in determining mRNA degradation rates via leave-one-feature-out analysis. Keywords: COVID-19 mRNA; bioinformatics
Patent filings > APPFT - Patent Applications


12/15/2022 — functional sequence, so that messenger RNA (mRNA) vaccine is optimized to be a self-amplifying messenger RNA (SAM) vaccine. r /> >4. The messenger ribonucleic acid
News > SciTechDaily - News

Promising New Treatment for Alzheimer’s Disease: Modifying Key Messenger RNA

03/22/2023 — by multiple interacting players, but a potentially important one is the methylation of messenger RNA within the myeloid cells. The most common type of mRNA methylation
Press releases > Businesswire - Health News

Arcturus Therapeutics to Present at the 41st Annual J.P. Morgan Healthcare Conference

12/19/2022 — expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and Influenza, and other programs
News > ACCESSWIRE - News

Moderna to Present at Cowen's 43rd Annual Health Care Conference

02/28/2023 — advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad
News > The Medical News

New analytical platform quantifies the structure of mRNA-based medicines

02/13/2023 — analysis that quantifies the structure of messenger RNA (mRNA) based medicines. They can elucidate mRNA sequences while quantifying "capping" at one end of the molecule and
Press releases > Businesswire - Health News

Arcturus Therapeutics to Attend Upcoming Investor Conferences

02/06/2023 — drug product manufacturing expertise. Arcturus’ diverse pipeline of RNA therapeutic and vaccine candidates includes mRNA vaccine programs for SARS-CoV-2 (COVID-19) and
Scientific studies > PubMed Articles

Comment on "Heterologous adenovirus-vector/messenger RNA regimen, humoral response and liver transplant recipients".

12/02/2022 — . Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients. D'Offizi G, Agrati C, Visco-Comandini U, Castilletti C
News > ACCESSWIRE news

Moderna to Host Fourth Annual Virtual Vaccines Day on April 11, 2023

03/24/2023 — messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio and
Press releases > Businesswire: Health press releases

Arcturus Therapeutics to Report First Quarter Financial Results and Provide Corporate Update on May 9, 2023

04/26/2023 — types of nucleic acid medicines including messenger RNA, small interfering RNA, circular RNA, antisense RNA, self-amplifying RNA, DNA, and gene editing therapeutics
News > News-Medical.net - News

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

01/29/2023 — women from initial COVID-19 messenger RNA (mRNA) vaccine trials. Nevertheless, a robust maternal immune response has been reported after vaccination with mRNA-lipid
Scientific studies > PubMed Abstracts

Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia.

12/23/2022 — , myelodysplastic syndrome or chronic myelomonocytic leukaemia were examined for protein (fluorescence-activated cell sorting) and messenger RNA (mRNA) expression (quantitative
Scientific studies > MDPI

The Origin of Translation: Bridging the Nucleotides and Peptides

12/22/2022 — template, transfer RNA as the adaptor, and ribosome RNA as the catalytic core. How tRNA and mRNA formed and how primal peptides were coded in the prebiotic era without
Patent filings > APPFT - Patent Grants

Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

01/03/2023 — messenger RNA (mRNA), the aa-tRNA binds to the ribosome and its amino acid is incorporated into the nascent protein chain. Since all tRNAs that base-pair with a specific codon
Scientific studies > PubMed Articles

RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system.

05/09/2023 — Posttranscriptional regulation of the maternal nanos mRNA is essential for the development of the anterior - posterior axis of the Drosophila embryo. The nanos RNA is regulated by the
Press releases > National Multiple Sclerosis Society press releases

Researchers report using novel mRNA “vaccine” to treat mice with MS-like disease – further research

05/17/2023 — lead to clinical trials in people. “A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis,” by Drs. Christina Krienke, Ugur Sahin, and colleagues, was published in Science on January 8, 2021 (Vol. 371, Issue 6525, pp. 145-153).
Press releases > Businesswire - Health News

CF Foundation Invests Up to $15M in ReCode Therapeutics for Development of mRNA Therapy

01/10/2023 — BETHESDA, Md.--( BUSINESS WIRE )--The Cystic Fibrosis Foundation will invest up to $15 million in ReCode Therapeutics for the development of its messenger RNA (mRNA
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